Skip to main content

Table 2 Variables and corresponding beta-coefficients of the time-dependent 10-year, early and late signatures

From: Novel 18-gene signature for predicting relapse in ER-positive, HER2-negative breast cancer

Variable

10-Year signature

Early signature

Late signature

ALDH1A1

  

−0.194

ANP32E

0.143

0.010

0.083

CRABP2

0.084

0.207

 

CXCL12

 

−0.183

 

CXCR4

0.142

 

0.056

EGFR

  

−0.030

ELF5

−0.046

−0.001

 

FGF2

−0.178

 

−0.232

IGF1

−0.029

−0.017

 

IGJ

−0.086

−0.037

−0.030

IL6ST

 

−0.044

 

LINC00341

− 0.463

− 0.362

− 0.392

LRRC48

 

− 0.104

 

MMP9

0.043

 

0.064

MPZL1

0.276

0.066

0.043

NUSAP1

0.088

0.065

 

PBX1

0.159

 

0.375

PDZK1

−0.011

 

−0.063

PGR

 

− 0.073

 

PRC1

 

0.019

 

RGL1

−0.429

− 0.166

− 0.161

RRM2

0.077

0.124

 

SFRP1

−0.017

 

−0.278

STC2

−0.087

−0.068

 

TNF

−0.029

 

−0.026

ZEB2

  

−0.138

CTS

0.514

0.409

0.516

  1. Positive coefficients are associated with higher recurrence risk; negative coefficients are associated with lower recurrence risk. Beta-coefficients were normalised by dividing them by the SD of the respective variables in the training population