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Table 2 Variables and corresponding beta-coefficients of the time-dependent 10-year, early and late signatures

From: Novel 18-gene signature for predicting relapse in ER-positive, HER2-negative breast cancer

Variable 10-Year signature Early signature Late signature
ALDH1A1    −0.194
ANP32E 0.143 0.010 0.083
CRABP2 0.084 0.207  
CXCL12   −0.183  
CXCR4 0.142   0.056
EGFR    −0.030
ELF5 −0.046 −0.001  
FGF2 −0.178   −0.232
IGF1 −0.029 −0.017  
IGJ −0.086 −0.037 −0.030
IL6ST   −0.044  
LINC00341 − 0.463 − 0.362 − 0.392
LRRC48   − 0.104  
MMP9 0.043   0.064
MPZL1 0.276 0.066 0.043
NUSAP1 0.088 0.065  
PBX1 0.159   0.375
PDZK1 −0.011   −0.063
PGR   − 0.073  
PRC1   0.019  
RGL1 −0.429 − 0.166 − 0.161
RRM2 0.077 0.124  
SFRP1 −0.017   −0.278
STC2 −0.087 −0.068  
TNF −0.029   −0.026
ZEB2    −0.138
CTS 0.514 0.409 0.516
  1. Positive coefficients are associated with higher recurrence risk; negative coefficients are associated with lower recurrence risk. Beta-coefficients were normalised by dividing them by the SD of the respective variables in the training population