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Table 1 Levels of specific human cytokines

From: Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models

Human cytokines

 

Serum

Tumor

Non-hNSG

hNSG

Non-hNSG

hNSG

IL-1B

0

0

5.3 ± 1.0

10.9 ± 0.8*

TNF-α

0

1.3 ± 0.5

25.4 ± 2.1

250.2 ± 35.4**

IL-5

0

1.5 ± 0.4

0

0

IL-2

0

1.8 ± 0.3

0

0

IL-7

0

2.1 ± 0.6

10.4 ± 0.2

28.4 ± 0.6**

IL-12

0

3.6 ± 0.3

0

0

IFN-γ

0

19.8 ± 5.4

0

11.75 ± 0.6**

IL-13

0

0

7.8 ± 0.5

16.60 ± 0.6**

IL-4

0

0

8.3 ± 0.4

21.40 ± 1.0**

GM-CSF

93.7 ± 5.6

94.8 ± 9.7

841.8 ± 93.9

3296.3 ± 235.2**

IL-6

45.1 ± 2.5

73.3 ± 2.6*

217.8 ± 12.5

1039.2 ± 100.4**

IL-8

2989.5 ± 527.8

2798.3 ± 503.9

1208.1 ± 114.9

1310 ± 61.7

  1. Abbreviations: GM-CSF Granulocyte-macrophage colony-stimulating factor, hNSG Humanized nonobese diabetic/severe combined immunodeficiency IL2Rγnull, IFN-γ Interferon-γ, IL Interleukin, TNF-α Tumor necrosis factor-α
  2. Cytokines were measured in samples of serum and tumor lysates of non-hNSG and hNSG mice harboring triple-negative breast cancer MC1 patient-derived xenografts. Values are expressed in picograms per milliliter (± SEM) (n = 4 NSG; n = 6 hNSG).*P < 0.05, **P < 0.01