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Table 1 Levels of specific human cytokines

From: Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models

Human cytokines
  Serum Tumor
Non-hNSG hNSG Non-hNSG hNSG
IL-1B 0 0 5.3 ± 1.0 10.9 ± 0.8*
TNF-α 0 1.3 ± 0.5 25.4 ± 2.1 250.2 ± 35.4**
IL-5 0 1.5 ± 0.4 0 0
IL-2 0 1.8 ± 0.3 0 0
IL-7 0 2.1 ± 0.6 10.4 ± 0.2 28.4 ± 0.6**
IL-12 0 3.6 ± 0.3 0 0
IFN-γ 0 19.8 ± 5.4 0 11.75 ± 0.6**
IL-13 0 0 7.8 ± 0.5 16.60 ± 0.6**
IL-4 0 0 8.3 ± 0.4 21.40 ± 1.0**
GM-CSF 93.7 ± 5.6 94.8 ± 9.7 841.8 ± 93.9 3296.3 ± 235.2**
IL-6 45.1 ± 2.5 73.3 ± 2.6* 217.8 ± 12.5 1039.2 ± 100.4**
IL-8 2989.5 ± 527.8 2798.3 ± 503.9 1208.1 ± 114.9 1310 ± 61.7
  1. Abbreviations: GM-CSF Granulocyte-macrophage colony-stimulating factor, hNSG Humanized nonobese diabetic/severe combined immunodeficiency IL2Rγnull, IFN-γ Interferon-γ, IL Interleukin, TNF-α Tumor necrosis factor-α
  2. Cytokines were measured in samples of serum and tumor lysates of non-hNSG and hNSG mice harboring triple-negative breast cancer MC1 patient-derived xenografts. Values are expressed in picograms per milliliter (± SEM) (n = 4 NSG; n = 6 hNSG).*P < 0.05, **P < 0.01