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Fig. 2 | Breast Cancer Research

Fig. 2

From: Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models

Fig. 2

In vivo effects of humanization of nonobese diabetic/severe combined immunodeficiency IL2Rγnull (NSG) mice in the growth and engraftment of triple-negative breast cancer (TNBC) patient-derived xenograft (PDX) tumor line MC1 (a) and human melanoma A375 cell line (b). Both humanized and nonhumanized female NSG mice (n = 10 in each group) were transplanted orthotopically with pieces of either the PDX tumor line MC1 (into the cleared mammary fat pad) or A375 cells (into the skin) and allowed to grow. Tumor volume was determined twice weekly. NS Nonsignificant; *P < 0.05, *** P < 0.001. c Flow cytometric analysis of human CD45+ cells and hCD20+ (B cells), hCD3+ (T cells), hCD33+ (myeloid lineage), hCD56+ (natural killer [NK] cells) and hCD68+ (macrophages) cell subpopulations determined in blood, spleen, bone marrow, and MC1 PDX tumors of the corresponding samples shown in (a) (n = 10)

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