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Table 5 Multivariate HR and 95% CI for the association between breast cancer risk factors and 10-year all-cause mortality and 5-year recurrence among women with luminal A-like subtype breast cancer

From: Breast cancer risk factors, survival and recurrence, and tumor molecular subtype: analysis of 3012 women from an indigenous Asian population

Risk factor

10-year all-cause mortality

5-year recurrence

N/events

HR1 (95% CI)

N/events

HRa (95% CI)

Ethnicity

 Chinese

539/38

1.00 (reference)

399/21

1.00 (reference)

 Malay

194/16

1.14 (0.59, 2.20)

154/7

0.81 (0.29, 2.27)

 Native

235/17

0.87 (0.41, 1.85)

190/11

0.90 (0.35, 2.29)

 P value

 

0.95

 

0.74

Menarche

  ≤ 12 yrs

338/13

1.00 (reference)

260/8

1.00 (reference)

 13 yrs

302/25

1.45 (0.70, 3.01)

235/13

1.69 (0.59, 4.81)

 14 yrs

156/10

1.23 (0.52, 2.92)

119/8

2.64 (0.87, 7.99)

  ≥ 15 yrs

172/23

2.28 (1.05, 4.95)

129/10

3.52 (1.10, 11.23)

 P value

 

0.06

 

0.02

Parity and BFb

 Nulliparous

229/23

1.00 (reference)

180/15

1.00 (reference)

 Parous and No BF

127/9

0.61 (0.26, 1.42)

87/5

0.53 (0.17. 1.59)

 Parous and BF

612/39

0.48 (0.27, 0.85)

476/19

0.28 (0.13, 0.64)

 P value

 

0.01

 

0.002

Age at FFPc

  < 21 yrs

111/9

1.00 (reference)

85/4

1.00 (reference)

 21–24.9 yrs

276/14

0.85 (0.31, 2.31)

220/4

0.40 (0.06, 2.28)

 25–30 yrs

262/22

0.71 (0.27, 1.82)

201/17

1.26 (0.30, 5.22)

  > 30 yrs

95/4

0.20 (0.04, 0.90)

73/1

0.26 (0.02, 3.09)

 P value

 

0.06

 

0.95

Family history

 No

804/53

1.00 (reference)

629/31

1.00 (referent)

 Yes

155/17

1.68 (0.91, 3.10)

122/7

0.75 (0.28, 2.02)

 P value

 

0.10

 

0.57

BMI

 18.5–24.9 kg/m2

160/6

1.00 (reference)

117/2

1.00 (reference)

  < 18.5 kg/m2

365/37

3.46 (1.21, 9.89)

285/22

4.31 (0.94, 19.83)

 P value

 

0.02

 

0.06

 25–29.9 kg/m2

310/21

3.14 (1.04, 9.50)

235/12

4.74 (1.00, 22.64)

 P value

 

0.04

 

0.05

  ≥ 30 kg/m2

133/7

1.38 (0.39, 4.86)

106/3

2.16 (0.34, 13.78)

 P value

 

0.61

 

0.41

  1. In bold are statistically significant estimates (P value < 0.05)
  2. aHR was mutually adjusted for ethnicity, menarche, parity and breastfeeding, age at FFP, family history, BMI, age, TNM stage, histologic grade, surgery, systemic therapy (endocrine (tamoxifen or AI versus none), chemotherapy (any regimen vs and radiotherapy (received versus none)
  3. bBF breastfeeding
  4. cFFP first full-term pregnancy