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Table 5 Multivariate HR and 95% CI for the association between breast cancer risk factors and 10-year all-cause mortality and 5-year recurrence among women with luminal A-like subtype breast cancer

From: Breast cancer risk factors, survival and recurrence, and tumor molecular subtype: analysis of 3012 women from an indigenous Asian population

Risk factor 10-year all-cause mortality 5-year recurrence
N/events HR1 (95% CI) N/events HRa (95% CI)
Ethnicity
 Chinese 539/38 1.00 (reference) 399/21 1.00 (reference)
 Malay 194/16 1.14 (0.59, 2.20) 154/7 0.81 (0.29, 2.27)
 Native 235/17 0.87 (0.41, 1.85) 190/11 0.90 (0.35, 2.29)
P value   0.95   0.74
Menarche
  ≤ 12 yrs 338/13 1.00 (reference) 260/8 1.00 (reference)
 13 yrs 302/25 1.45 (0.70, 3.01) 235/13 1.69 (0.59, 4.81)
 14 yrs 156/10 1.23 (0.52, 2.92) 119/8 2.64 (0.87, 7.99)
  ≥ 15 yrs 172/23 2.28 (1.05, 4.95) 129/10 3.52 (1.10, 11.23)
P value   0.06   0.02
Parity and BFb
 Nulliparous 229/23 1.00 (reference) 180/15 1.00 (reference)
 Parous and No BF 127/9 0.61 (0.26, 1.42) 87/5 0.53 (0.17. 1.59)
 Parous and BF 612/39 0.48 (0.27, 0.85) 476/19 0.28 (0.13, 0.64)
P value   0.01   0.002
Age at FFPc
  < 21 yrs 111/9 1.00 (reference) 85/4 1.00 (reference)
 21–24.9 yrs 276/14 0.85 (0.31, 2.31) 220/4 0.40 (0.06, 2.28)
 25–30 yrs 262/22 0.71 (0.27, 1.82) 201/17 1.26 (0.30, 5.22)
  > 30 yrs 95/4 0.20 (0.04, 0.90) 73/1 0.26 (0.02, 3.09)
P value   0.06   0.95
Family history
 No 804/53 1.00 (reference) 629/31 1.00 (referent)
 Yes 155/17 1.68 (0.91, 3.10) 122/7 0.75 (0.28, 2.02)
P value   0.10   0.57
BMI
 18.5–24.9 kg/m2 160/6 1.00 (reference) 117/2 1.00 (reference)
  < 18.5 kg/m2 365/37 3.46 (1.21, 9.89) 285/22 4.31 (0.94, 19.83)
P value   0.02   0.06
 25–29.9 kg/m2 310/21 3.14 (1.04, 9.50) 235/12 4.74 (1.00, 22.64)
P value   0.04   0.05
  ≥ 30 kg/m2 133/7 1.38 (0.39, 4.86) 106/3 2.16 (0.34, 13.78)
P value   0.61   0.41
  1. In bold are statistically significant estimates (P value < 0.05)
  2. aHR was mutually adjusted for ethnicity, menarche, parity and breastfeeding, age at FFP, family history, BMI, age, TNM stage, histologic grade, surgery, systemic therapy (endocrine (tamoxifen or AI versus none), chemotherapy (any regimen vs and radiotherapy (received versus none)
  3. bBF breastfeeding
  4. cFFP first full-term pregnancy