Advertisement
Table 4 HR and 95% CI for the associations between risk factors and 5-year recurrence by tumor molecular subtype
| Risk factora | Recurrence after 5 years | P-hetd | |||||||
|---|---|---|---|---|---|---|---|---|---|
| A-like | B-like | HER2-enriched | Triple-negative | ||||||
| N/events | HR (95% CI) | N/events | HR (95% CI) | N/events | HR (95% CI) | N/events | HR (95% CI) | ||
| Ethnicity | |||||||||
| Chinese | 567/34 | 1.00 (reference) | 435/49 | 1.00 (reference) | 180/30 | 1.00 (reference) | 275/38 | 1.00 (reference) | 0.96 |
| Malay | 204/8 | 1.01 (0.39, 2.60) | 263/30 | 0.81 (0.45, 1.45) | 104/17 | 0.69 (0.31, 1.51) | 155/24 | 1.11 (0.61, 2.02) | |
| Native | 245/16 | 1.17 (0.49, 2.79) | 291/22 | 0.84 (0.46, 1.55) | 103/10 | 0.47 (0.18, 1.23) | 190/22 | 0.67 (0.34, 1.34) | |
| P value | 0.75 | 0.55 | 0.11 | 0.32 | |||||
| Menarche | |||||||||
| ≤ 12 yrs | 344/13 | 1.00 (reference) | 326/38 | 1.00 (reference) | 118/14 | 1.00 (reference) | 190/34 | 1.00 (reference) | 0.07 |
| 13 yrs | 318/17 | 1.55 (0.57, 4.23) | 340/31 | 1.03 (0.58, 1.82) | 148/21 | 1.52 (0.69, 3.33) | 201/24 | 0.72 (0.38, 1.37) | |
| 14 yrs | 163/14 | 2.51 (0.86, 7.33) | 167/21 | 0.81 (0.40, 1.64) | 60/9 | 0.56 (0.16, 1.92) | 111/13 | 0.65 (0.30, 1.43) | |
| ≥ 15 yrs | 184/13 | 3.26 (1.08, 9.92) | 148/11 | 0.77 (0.35, 1.68) | 57/12 | 1.11 (0.38, 3.28) | 113/12 | 0.61 (0.27, 1.36) | |
| P value | 0.02 | 0.41 | 0.81 | 0.18 | |||||
| Parity and BFc | |||||||||
| Nulliparous | 242/19 | 1.00 (reference) | 224/16 | 1.00 (reference) | 77/12 | 1.00 (reference) | 128/19 | 1.00 (reference) | 0.56 |
| Parous and No BF | 133/7 | 0.55 (0.20, 1.50) | 103/14 | 1.86 (0.76, 4.56) | 31/7 | 1.35 (0.39, 4.64) | 64/17 | 1.57 (0.67, 3.66) | |
| Parous and BF | 641/32 | 0.27 (0.12, 0.58) | 662/71 | 1.63 (0.81, 3.28) | 279/38 | 0.58 (0.25, 1.34) | 428/48 | 0.77 (0.39, 1.52) | |
| P value | 0.001 | 0.23 | 0.15 | 0.28 | |||||
| Age at FFPd | |||||||||
| < 25 | 400/13 | 1.00 (reference) | 445/44 | 1.00 (reference) | 183/30 | 1.00 (reference) | 294/41 | 1.00 (reference) | 0.52 |
| ≥ 25 | 374/26 | 1.69 (0.66, 4.34) | 320/41 | 1.32 (0.78, 2.22) | 127/15 | 0.50 (0.21, 1.16) | 197/23 | 0.75 (0.41, 1.39) | |
| P value | 0.27 | 0.28 | 0.10 | 0.36 | |||||
| Family history | |||||||||
| No | 840/42 | 1.00 (reference) | 854/85 | 1.00 (reference) | 338/49 | 1.00 (reference) | 516/66 | 1.00 (reference) | 0.94 |
| Yes | 160/13 | 0.77 (0.29, 2.03) | 119/14 | 1.17 (0.60, 2.28) | 46/7 | 1.24 (0.45, 3.35) | 92/12 | 0.85 (0.43, 1.70) | |
| P value | 0.60 | 0.64 | 0.67 | ||||||
| BMI, kg/m2 | |||||||||
| 18.5–24.9 | 160/6 | 1.00 (referent) | 172/14 | 1.00 (referent) | 68/11 | 1.00 (referent) | 114/16 | 1.00 (referent) | 0.98 |
| < 18.5 | 373/30 | 3.97 (0.91, 17.34) | 336/29 | 1.37 (0.62, 3.03) | 163/21 | 0.50 (0.20, 1.27) | 240/30 | 1.01 (0.51, 2.01) | |
| P value | 0.06 | 0.43 | 0.15 | 0.97 | |||||
| 25–30 | 317/16 | 3.40 (0.75, 15.42) | 301/37 | 2.02 (0.95, 4.29) | 104/15 | 0.70 (0.27, 1.81) | 177/24 | 0.83 (0.39, 1.73) | |
| P value | 0.11 | 0.06 | 0.46 | 0.62 | |||||
| > 30 | 136/5 | 1.65 (0.27, 10.15) | 148/15 | 1.28 (0.53, 3.12) | 38/7 | 1.41 (0.46, 4.27) | 66/13 | 0.89 (0.35, 2.25) | |
| P value | 0.59 | 0.58 | 0.55 | 0.81 | |||||
