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Table 3 HR and 95% CI for the associations between risk factors and 10-year all-cause mortality by tumor molecular subtype
| Risk factor1a | 10-year all-cause mortality | P hetd | |||||||
|---|---|---|---|---|---|---|---|---|---|
| A-like | B-like | HER2-enriched | Triple-negative | ||||||
| N/events | HR (95% CI) | N/events | HR (95% CI) | N/events | HR (95% CI) | N/events | HR (95% CI) | ||
| Ethnicity | |||||||||
| Chinese | 567/39 | 1.00 (reference) | 435/41 | 1.00 (reference) | 180/38 | 1.00 (reference) | 275/57 | 1.00 (reference) | 0.81 |
| Malay | 204/17 | 1.23 (0.65, 2.34) | 263/70 | 2.32 (1.49, 3.60) | 104/29 | 1.11 (0.63, 1.96) | 155/54 | 1.22 (0.79, 1.89) | |
| Native | 245/19 | 1.04 (0.52, 2.05) | 291/39 | 1.68 (1.02, 2.77) | 103/20 | 0.93 (0.48, 1.79) | 190/41 | 1.06 (0.67, 1.67) | |
| P value | 0.80 | 0.03 | 0.87 | 0.77 | |||||
| Menarche | |||||||||
| ≤ 12 yrs | 344/14 | 1.00 (reference) | 326/52 | 1.00 (reference) | 118/23 | 1.00 (reference) | 190/46 | 1.00 (reference) | 0.06 |
| 13 yrs | 318/26 | 1.53 (0.76, 3.11) | 340/44 | 0.88 (0.55, 1.40) | 148/29 | 0.84 (0.45, 1.57) | 201/46 | 1.21 (0.76, 1.92) | |
| 14 yrs | 163/11 | 1.25 (0.54, 2.91) | 167/27 | 0.86 (0.50, 1.48) | 60/22 | 0.92 (0.47, 1.80) | 111/26 | 1.05 (0.61, 1.80) | |
| ≥ 15 yrs | 184/23 | 2.25 (1.06, 4.78) | 148/27 | 0.84 (0.49, 1.42) | 57/11 | 0.49 (0.21, 1.11) | 113/31 | 0.89 (0.52, 1.55) | |
| P value | 0.06 | 0.49 | 0.15 | 0.66 | |||||
| Parity and BFb | |||||||||
| Nulliparous | 242/24 | 1.00 (reference) | 224/36 | 1.00 (reference) | 77/18 | 1.00 (reference) | 128/40 | 1.00 (reference) | 0.28 |
| Parous and No BF | 133/10 | 0.59 (0.27, 1.32) | 103/12 | 0.81 (0.37, 1.75) | 31/8 | 0.87 (0.34, 2.25) | 64/20 | 1.02 (0.52, 1.96) | |
| Parous and BF | 641/41 | 0.46 (0.26, 0.81) | 662/102 | 0.99 (0.64, 1.56) | 279/61 | 0.61 (0.33, 1.14) | 428/92 | 0.86 (0.55, 1.34) | |
| P value | 0.009 | 0.91 | 0.11 | 0.48 | |||||
| Age at FFPc | |||||||||
| < 21 yrs | 116/10 | 1.00 (reference) | 158/32 | 1.00 (reference) | 54/13 | 1.00 (reference) | 95/19 | 1.00 (reference) | 0.22 |
| 21–24.9 yrs | 284/14 | 0.99 (0.38, 2.55) | 287/33 | 1.30 (0.75, 2.25) | 129/28 | 0.83 (0.37, 1.84) | 199/42 | 0.71 (0.39, 1.29) | |
| 25–30 yrs | 275/23 | 0.85 (0.41, 1.73) | 248/39 | 1.14 (0.69, 1.90) | 103/22 | 0.77 (0.40, 1.49) | 154/41 | 0.98 (0.60, 1.60) | |
| > 30 yrs | 99/4 | 0.36 (0.10, 1.29) | 72/10 | 1.34 (0.64, 2.81) | 24/6 | 0.78 (0.25, 2.46) | 43/9 | 0.53 (0.23, 1.24) | |
| P value | 0.08 | 0.92 | 0.15 | 0.58 | |||||
| Family history | |||||||||
| No | 840/56 | 1.00 (reference) | 854/131 | 1.00 (reference) | 338/73 | 1.00 (reference) | 516/122 | 1.00 (reference) | 0.25 |
| Yes | 160/17 | 1.70 (0.93, 3.08) | 119/17 | 1.05 (0.59, 1.88) | 46/13 | 1.47 (0.76, 2.82) | 92/22 | 0.77 (0.46, 1.27) | |
| P value | 0.08 | 0.86 | |||||||
| BMI, kg/m2 | |||||||||
| 18.5–24.9 | 160/6 | 1.00 (reference) | 172/25 | 1.00 (reference) | 68/15 | 1.00 (reference) | 114/25 | 1.00 (reference) | 0.80 |
| < 18.5 | 373/38 | 3.42 (1.20, 9.71) | 336/43 | 1.06 (0.62, 1.82) | 163/37 | 0.83 (0.44, 1.57) | 240/63 | 1.15 (0.70, 1.91) | |
| P value | 0.02 | 0.83 | 0.58 | 0.56 | |||||
| 25–30 | 317/21 | 2.88 (0.97, 8.59) | 301/49 | 1.30 (0.77, 2.20) | 104/19 | 0.80 (0.39, 1.64) | 177/40 | 0.92 (0.54, 1.57) | |
| P value | 0.06 | 0.32 | 0.54 | 0.77 | |||||
| > 30 | 136/7 | 1.30 (0.37, 4.52) | 148/23 | 1.12 (0.61, 2.05) | 38/10 | 1.23 (0.52, 2.90) | 66/18 | 1.21 (0.63, 2.32) | |
| P value | 0.68 | 0.71 | 0.63 | 0.57 | |||||
