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Table 2 OR and 95% CI from a polytomous logistic regression model testing the associations between breast cancer risk factors and tumor molecular subtype

From: Breast cancer risk factors, survival and recurrence, and tumor molecular subtype: analysis of 3012 women from an indigenous Asian population

Risk factor Subtype
A-like (comparison group) B-like HER2-enriched Triple-negative
N N ORa (95% CI) N OR (95% CI) N OR (95% CI)
Ethnicity
 Chinese 567 435 1.00 (reference) 180 1.00 (reference) 275 1.00 (reference)
 Malay 204 263 1.50 (1.18, 1.90) 104 1.54 (1.13, 2.11) 155 1.51 (1.14, 1.98)
 Native 245 291 1.39 (1.10, 1.76) 103 1.21 (0.88, 1.66) 190 1.50 (1.15, 1.95)
P value    0.001   0.10   < 0.001
Menarche
  ≤ 12 yrs 344 326 1.00 (reference) 118 1.00 (reference) 190 1.00 (reference)
 13 yrs 318 340 1.14 (0.91, 1.43) 148 1.31 (0.98, 1.77) 201 1.15 (0.88, 1.49)
 14 yrs 163 167 1.04 (0.79, 1.38) 60 1.02 (0.70, 1.48) 111 1.18 (0.86, 1.61)
  ≥ 15 yrs 184 148 0.83 (0.63, 1.10) 57 0.87 (0.59, 1.28) 113 1.10 (0.80, 1.50)
P value    0.43   0.51   0.31
Parity and BFb
 Nulliparous 242 224 1.00 (reference) 77 1.00 (reference) 128 1.00 (reference)
 Parous and No BF 133 103 1.26 (0.84, 1.90) 31 1.07 (0.76, 1.52) 64 1.25 (0.77, 2.00)
 Parous and BF 641 662 1.44 (1.05, 1.98) 279 1.64 (1.06, 2.55) 428 1.54 (1.07, 2.22)
P value    0.17   0.005   0.12
Age at FFPc
  < 21 yrs 116 158 1.00 (reference) 54 1.00 (reference) 95 1.00 (reference)
 21–24.9 yrs 284 287 0.78 (0.57, 1.05) 129 1.01 (0.67, 1.51) 199 0.90 (0.64, 1.26)
 25–30 yrs 275 248 0.77 (0.57, 1.06) 103 0.91 (0.60, 1.38) 154 0.77 (0.54, 1.09)
  > 30 yrs 99 72 0.63 (0.42, 0.94) 24 0.57 (0.32, 1.02) 43 0.58 (0.36, 0.93)
P value    0.35   0.06   0.38
Family history
 No 840 854 1.00 (reference) 338 1.00 (reference) 516 1.00 (reference)
 Yes 160 119 0.72 (0.55, 0.94) 46 0.71 (0.49, 1.02) 92 0.92 (0.69, 1.23)
P value    0.02   0.05   0.62
BMI, kg/m2
 18.5–24.9 160 172 1.00 (reference) 68 1.00 (reference) 114 1.00 (reference)
  < 18.5 373 336 0.89 (0.69, 1.17) 163 1.07 (0.76, 1.51) 240 0.96 (0.72, 1.29)
P value    0.38   0.65   0.76
 25–29.9 317 301 0.86 (0.65, 1.12) 104 0.74 (0.51, 1.06) 177 0.75 (0.55, 1.02)
P value    0.27   0.13   0.08
  ≥ 30 136 148 0.90 (0.65, 1.24) 38 0.55 (0.34, 0.89) 66 0.59 (0.40, 0.88)
P value    0.62   0.02   0.01
  1. Statistically significant (P value < 0.05) estimates are indicated in bold
  2. aOR and corresponding estimates are from a single polytomous logistic regression model that was mutually adjusted for ethnicity, menarche, parity and breastfeeding, age at FFP, family history, BMI and age
  3. bBF breastfeeding
  4. cFFP first full-term pregnancy