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Table 2 OR and 95% CI from a polytomous logistic regression model testing the associations between breast cancer risk factors and tumor molecular subtype

From: Breast cancer risk factors, survival and recurrence, and tumor molecular subtype: analysis of 3012 women from an indigenous Asian population

Risk factor

Subtype

A-like (comparison group)

B-like

HER2-enriched

Triple-negative

N

N

ORa (95% CI)

N

OR (95% CI)

N

OR (95% CI)

Ethnicity

 Chinese

567

435

1.00 (reference)

180

1.00 (reference)

275

1.00 (reference)

 Malay

204

263

1.50 (1.18, 1.90)

104

1.54 (1.13, 2.11)

155

1.51 (1.14, 1.98)

 Native

245

291

1.39 (1.10, 1.76)

103

1.21 (0.88, 1.66)

190

1.50 (1.15, 1.95)

 P value

  

0.001

 

0.10

 

< 0.001

Menarche

  ≤ 12 yrs

344

326

1.00 (reference)

118

1.00 (reference)

190

1.00 (reference)

 13 yrs

318

340

1.14 (0.91, 1.43)

148

1.31 (0.98, 1.77)

201

1.15 (0.88, 1.49)

 14 yrs

163

167

1.04 (0.79, 1.38)

60

1.02 (0.70, 1.48)

111

1.18 (0.86, 1.61)

  ≥ 15 yrs

184

148

0.83 (0.63, 1.10)

57

0.87 (0.59, 1.28)

113

1.10 (0.80, 1.50)

 P value

  

0.43

 

0.51

 

0.31

Parity and BFb

 Nulliparous

242

224

1.00 (reference)

77

1.00 (reference)

128

1.00 (reference)

 Parous and No BF

133

103

1.26 (0.84, 1.90)

31

1.07 (0.76, 1.52)

64

1.25 (0.77, 2.00)

 Parous and BF

641

662

1.44 (1.05, 1.98)

279

1.64 (1.06, 2.55)

428

1.54 (1.07, 2.22)

 P value

  

0.17

 

0.005

 

0.12

Age at FFPc

  < 21 yrs

116

158

1.00 (reference)

54

1.00 (reference)

95

1.00 (reference)

 21–24.9 yrs

284

287

0.78 (0.57, 1.05)

129

1.01 (0.67, 1.51)

199

0.90 (0.64, 1.26)

 25–30 yrs

275

248

0.77 (0.57, 1.06)

103

0.91 (0.60, 1.38)

154

0.77 (0.54, 1.09)

  > 30 yrs

99

72

0.63 (0.42, 0.94)

24

0.57 (0.32, 1.02)

43

0.58 (0.36, 0.93)

 P value

  

0.35

 

0.06

 

0.38

Family history

 No

840

854

1.00 (reference)

338

1.00 (reference)

516

1.00 (reference)

 Yes

160

119

0.72 (0.55, 0.94)

46

0.71 (0.49, 1.02)

92

0.92 (0.69, 1.23)

 P value

  

0.02

 

0.05

 

0.62

BMI, kg/m2

 18.5–24.9

160

172

1.00 (reference)

68

1.00 (reference)

114

1.00 (reference)

  < 18.5

373

336

0.89 (0.69, 1.17)

163

1.07 (0.76, 1.51)

240

0.96 (0.72, 1.29)

 P value

  

0.38

 

0.65

 

0.76

 25–29.9

317

301

0.86 (0.65, 1.12)

104

0.74 (0.51, 1.06)

177

0.75 (0.55, 1.02)

 P value

  

0.27

 

0.13

 

0.08

  ≥ 30

136

148

0.90 (0.65, 1.24)

38

0.55 (0.34, 0.89)

66

0.59 (0.40, 0.88)

 P value

  

0.62

 

0.02

 

0.01

  1. Statistically significant (P value < 0.05) estimates are indicated in bold
  2. aOR and corresponding estimates are from a single polytomous logistic regression model that was mutually adjusted for ethnicity, menarche, parity and breastfeeding, age at FFP, family history, BMI and age
  3. bBF breastfeeding
  4. cFFP first full-term pregnancy