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Fig. 7 | Breast Cancer Research

Fig. 7

From: Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance

Fig. 7

Collagen XIII promotes cancer metastasis in xenograft models. a Kaplan-Meier analysis of distant recurrence free survival of ER negative breast cancer patients; the patients were equally divided into high and low expression levels of collagen XIII. n = 170. **p <0.01. b IVIS images (left) and quantification (right) of tail vain lung metastasis in control and Col13−/− 231-luc-D3H2LN cells injected mice. Data are presented as the mean ± s.e.m.; n = 5, * p < 0.05. c H&E staining (left) and quantification (right) of lung metastasis nodules in control and Col13−/− 231-luc-D3H2LN cells injected mice; n = 4; * p < 0.05. d IVIS images (left) and quantification (right) showed over all metastasis of control and Col13−/− 231-luc-D3H2LN cells via intracardiac inoculation. Data are presented as the mean ± s.e.m.; n = 3, p = 0.09. e Tumor growth curve of control and Col13−/− 231-luc-D3H2LN implanted mice. On day 23 and 25 showed statistical significance; n = 6; * p < 0.05. f H&E staining (left) and quantification (right) of lung metastasis nodules in mice 3 weeks after primary tumor removal; n = 5; p = 0.164

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