Table 1 Distribution of benign breast features and other characteristics by fibroadenoma status
Characteristic | Status, n (%)a | P valueb | |
|---|---|---|---|
No fibroadenoma 2047 (53.2) | Fibroadenoma 1798 (46.8) | ||
Age at benign biopsy, years | < 0.001 | ||
< 40 | 387 (18.9) | 573 (31.9) | |
40–49 | 692 (33.8) | 582 (32.4) | |
50–59 | 577 (28.2) | 374 (20.8) | |
60–69 | 249 (12.2) | 164 (9.1) | |
70+ | 142 (6.9) | 105 (5.8) | |
Biopsy type | < 0.001 | ||
Excisional | 826 (40.4) | 536 (30.8) | |
Core needle | 1221 (59.6) | 1262 (70.2) | |
Apocrine metaplasia | < 0.001 | ||
Absent | 1202 (58.7) | 1401 (82.3) | |
Present | 845 (41.3) | 301 (17.7) | |
Ductal hyperplasia | < 0.001 | ||
Absent | 1272 (62.1) | 1365 (80.6) | |
Present | 775 (37.9) | 329 (19.4) | |
Lobular hyperplasia | 0.008 | ||
Absent | 2012 (98.3) | 1662 (99.3) | |
Present | 34 (1.7) | 11 (0.7) | |
Calcifications | < 0.001 | ||
Absent | 1209 (59.1) | 1229 (70.8) | |
Present | 837 (40.9) | 507 (29.2) | |
Cysts | < 0.001 | ||
Absent | 970 (47.4) | 1339 (78.9) | |
Present | 1076 (52.6) | 359 (21.1) | |
Duct ectasia | < 0.001 | ||
Absent | 1652 (80.7) | 1546 (91.0) | |
Present | 394 (19.3) | 152 (9.0) | |
Fibrosis | < 0.001 | ||
Absent | 648 (31.7) | 1031 (63.8) | |
Present | 1397 (68.3) | 586 (36.2) | |
Intraductal papilloma | < 0.001 | ||
Absent | 1662 (81.2) | 1629 (96.1) | |
Present | 385 (18.8) | 66 (3.9) | |
Sclerosing adenosis | < 0.001 | ||
Absent | 1416 (69.2) | 1404 (82.7) | |
Present | 630 (30.8) | 294 (17.3) | |
Columnar alterations | < 0.001 | ||
Absent | 1302 (63.6) | 1439 (84.7) | |
Present | 744 (30.8) | 259 (15.3) | |
Radial scar | < 0.001 | ||
Absent | 1975 (96.5) | 1665 (98.6) | |
Present | 71 (3.5) | 23 (1.4) | |
Dupont and Page criteria | < 0.001 | ||
Nonproliferative disease | 868 (42.4) | 1325 (73.7) | |
Proliferative disease without atypia | 1054 (51.5) | 450 (25.0) | |
Proliferative disease with atypia | 125 (6.1) | 23 (1.3) | |
Developed breast cancer | < 0.001 | ||
No | 1902 (92.9) | 1722 (95.8) | |
Yes | 145 (7.1) | 76 (4.2) |