| No. of subjects | Geometric mean (95% CI) | |||||
Percent dense volume (%) | Absolute dense volume (cm3) | Absolute nondense volume (cm3) | |||||
Age- and BMI-adjusted | Multivariable-adjusted | Age- and BMI-adjusted | Multivariable-adjusted | Age- and BMI-adjusted | Multivariable-adjusted | ||
Insulin-treated T1D | |||||||
 Nondiabetics | 610 | 8.7 (8.5; 9.1) | 8.7 (8.4; 9.0) | 59.6 (57.4; 61.9) | 59.7 (57.5; 62.1) | 610.3 (589.5; 631.8) | 615.0 (593.8; 637.0) |
 T1D - insulin any | 122 | 11.3 (10.4; 12.2) | 11.4 (10.5; 12.4) | 65.7 (60.4; 71.5) | 64.7 (58.8; 71.1) | 509.8 (471.8; 550.9) | 490.5 (450.0; 534.6) |
 P value |  | < 0.001 | < 0.001 | 0.01 | 0.14 | < 0.001 | < 0.001 |
 Nondiabetics | 610 | 8.7 (8.5; 9.1) | 8.7 (8.4; 9.0) | 59.6 (57.4; 61.9) | 59.8 (57.6; 62.2) | 611.0 (590.2; 632.6) | 615.7 (594.5; 637.7) |
 T1D - nonglargine insulin | 57 | 11.0 (9.8; 12.3) | 11.5 (10.2; 13.0) | 60.0 (52.7; 68.2) | 59.1 (51.5; 67.9) | 477.1 (423.9; 536.9) | 447.2 (394.3; 507.2) |
 T1D - glargine insulin | 65 | 11.5(10.4; 12.8) | 11.4 (10.2; 12.7) | 70.9 (63.2; 79.6) | 69.2 (61.3; 78.2) | 534.1 (480.3; 593.9) | 525.9 (470.8; 587.4) |
 P value |  | < 0.001 | < 0.001 | 0.02 | 0.07 | < 0.001 | < 0.001 |
Insulin-treated T2D | |||||||
 Nondiabetics | 1161 | 6.5 (6.4; 6.7) | 6.5 (6.3; 6.6) | 52.7 (51.3; 54.1) | 52.6 (51.2; 54.0) | 746.9 (728.3; 766.0) | 753.5(734.5; 773.0) |
 T2D - insulin any | 237 | 7.4 (6.9; 8.0) | 7.8 (7.2; 8.4) | 57.5 (53.5; 61.9) | 58.0 (53.7; 62.7) | 708.9 (661.3; 760.0) | 679.1(630.9; 731.0) |
 P value |  | 0.002 | 0 | 0.004 | 0.03 | 0.20 | 0.02 |
 Nondiabetics | 1161 | 6.5 (6.4; 6.7) | 6.5 (6.3; 6.7) | 52.8 (51.4; 54.3) | 52.7 (51.3; 54.2) | 746.6 (727.8; 765.8) | 753.0 (733.9; 772.6) |
 T2D - nonglargine insulin | 163 | 7.1 (6.5; 7.8) | 7.5 (6.8; 8.2) | 55.2 (50.4; 60.4) | 56.0 (50.9; 61.5) | 715.3 (656.1; 779.9) | 687.1 (628.0; 751.7) |
 T2D – glargine insulin | 74 | 7.9 (7.1; 8.7) | 8.2 (7.4; 9.1) | 60.7 (54.9; 67.1) | 60.7 (54.8; 67.3) | 700.8 (636.7; 771.4) | 669.2 (606.6; 738.3) |
 P value |  | 0.002 | <  0.001 | 0.04 | 0.04 | 0.41 | 0.05 |
 |  | Percentage difference (95% CI) | |||||
Percent dense volume | Absolute dense volume | Absolute nondense volume | |||||
Age- and BMI-adjusted | Multivariable-adjusted | Age- and BMI-adjusted | Multivariable-adjusted | Age- and BMI-adjusted | Multivariable-adjusted | ||
Insulin-treated T1D | |||||||
 Nondiabetics | 610 | Reference | Reference | Reference | Reference | Reference | Reference |
 T1D - insulin any | 122 | 28.8 (18.3; 40.2) | 31.2 (19.5; 44.0) | 10.3 (0.5; 21.0) | 8.2 (−2.6; 20.3) | −16.5 (−23.3; −9.0) | −20.2 (−27.6; −12.2) |
 Nondiabetics | 610 | Reference | Reference | Reference | Reference | Reference | Reference |
 T1D - nonglargine insulin | 57 | 25.6 (11.2; 41.8) | 31.8(15.7; 50.2) | 0.6 (− 12.1; 15.2) | −1.2 (− 14.7; 14.4) | −21.9 (−31.0; − 11.6) | −27.4 (−36.5; − 17.0) |
 T1D - glargine insulin | 65 | 31.3 (17.7; 46.5) | 30.7 (16.5; 46.6) | 19.1 (5.4; 34.5) | 15.7 (1.7; 31.7) | −12.6 (− 21.8; − 2.3) | −14.6 (− 24.1; − 3.9) |
Insulin-treated T2D | |||||||
 Nondiabetics | 1161 | Reference | Reference | Reference | Reference | Reference | Reference |
 T2D - insulin any | 237 | 13.7 (4.7; 23.6) | 20.5 (10.3; 31.6) | 9.2 (0.4; 18.7) | 10.3 (0.9; 20.6) | −5.1 (−12.4; 2.8) | −9.9 (− 17.2; − 1.9) |
 Nondiabetics | 1161 | Reference | Reference | Reference | Reference | Reference | Reference |
 T2D - nonglargine insulin | 163 | 8.3 (−2.1; 19.7) | 15.0 (3.6; 27.7) | 4.5 (− 5.5; 15.6) | 6.2 (−4.5; 18.1) | −4.2 (−13.0; 5.5) | −8.8 (− 17.5; 1.0) |
 T2D – glargine insulin | 74 | 20.4 (8.3; 33.8) | 26.9 (13.8; 41.6) | 14.9 (3.3; 27.8) | 15.2 (3.1; 28.6) | −6.1 (−15.2; 3.9) | −11.1 (−20.0; −1.3) |