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Table 1 Screening performance measures among Volpara density grade categories

From: Volumetric breast density and risk of advanced cancers after a negative screening episode: a cohort study

  Total VDG1 VDG2 VDG3 VDG4 p trend
BC incidence (‰ (95% CI)) 5.7 (5.0–6.5) 3.7 (2.5–5.4) 5.1 (3.8–6.8) 5.4 (4.3–6.7) 9.1 (7.1–11.5) < 0.001
 BC cases n = 216 n = 27 n = 48 n = 73 n = 68  
Only invasive BC incidence (‰ (95% CI)) 4.4 (3.8–5.1) 3.5 (2.4–5.2) 3.7 (2.7–5.2) 3.6 (2.7–4.8) 7.5 (5.7–9.7) < 0.001
 Only invasive BC cases n = 166 n = 26 n = 35 n = 49 n = 56  
Screened 1st round (N) 15,952 3109 3959 5727 3157  
Recall rate 1st round (% (95% CI)) 13.4 (12.8–13.9) 9.2 (8.2–10.3) 12.9 (11.9–14.0) 14.7 (13.8–15.7) 15.6 (14.3–16.9) < 0.001
Detection rate 1st round (‰ (95% CI)) 7.1 (5.9–8.6) 6.4 (3.9–9.9) 7.1 (4.7–10.2) 6.6 (4.7–9.1) 8.9 (5.9–12.8) 0.624
 Screen-detected 1st round n = 114 n = 20 n = 28 n = 38 n = 28  
Interval cancer rate 1st round (‰ (95% CI)) 2.5 (1.8–3.4) 0.6 (0.1–2.3) 1.3 (0.4–3.0) 1.9 (1.0–3.5) 7.0 (4.4–10.6) < 0.001
 Interval cancers n = 40 n = 2 n = 5 n = 11 n = 22  
 Interval cancers 0–12 months n = 12 n = 1 n = 2 n = 1 n = 8  
 Interval cancers 13 months or more n = 28 n = 1 n = 3 n = 10 n = 14  
Screened 2nd round (N) 12,582 2509 3119 4522 2432  
Recall rate 2nd round (% (95% CI)) 8.5 (8.0–9.0) 5.3 (4.5–6.3) 7.0 (6.1–7.9) 10.0 (9.1–10.9) 10.9 (9.7–12.2) < 0.001
Detection rate 2nd round (‰ (95% CI)) 4.9 (3.8–6.3) 2.0 (0.6–4.6) 4.8 (2.7–7.9) 5.3 (3.4–7.9) 7.4 (4.4–11.7) 0.055
 Screen-detected 2nd round n = 62 n = 5 n = 15 n = 24 n = 18  
  1. VDG Volpara density grade, BC breast cancer