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Fig. 2 | Breast Cancer Research

Fig. 2

From: TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells

Fig. 2

AP20187-induced changes of gene expression in DCIS-iFGFR1 cells identified by RNA-Seq. a Venn diagrams for the numbers of mRNAs detected in DCIS-iFGFR1 cells treated with vehicle, AP20187 for 3 h and AP20187 for 16 h as indicated. Three independent RNA samples were assayed by RNA-Seq in each group. Total number of mRNAs detected in each group and expression relationships among all three groups are indicated. b Comparison of AP20187-induced mRNA expression changes at different time points of treatment and identification of consecutively upregulated and downregulated mRNAs changed by AP20187 treatment. c Heatmap for the expression levels of the consecutively upregulated 80 genes and downregulated 68 genes. d Real-time RT-qPCR measurement of the indicated mRNA expression levels in DCIS-iFGFR1 cells with vehicle treatment (0) or AP20187 treatment for 3 or 16 h as indicated. *p < 0.05; **p < 0.01; ***p < 0.001; and ****p < 0.0001 by unpaired Student’s t test

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