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Fig. 5 | Breast Cancer Research

Fig. 5

From: Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers

Fig. 5

In vivo effects of human epidermal growth factor receptor 3 (HER3) vaccine-induced antibody (HER3-VIA) in lapatinib-refractory rBT474 SCID tumor xenografts. a Flow cytometry analysis of HER2/HER3 expression (filled histograms) by BT474 and rBT474 cells. Mean fluorescence intensities are shown in each histogram. b The lapatinib-refractory cell line rBT474 was implanted into SCID mice and HER3-VIA was administered and tumor size was measured every 2-3 days : *p < 0.01). c Western blot analysis of excised tumors probing for downstream signaling intermediaries of HER3 activation. GFP, green fluorescence protein

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Breast Cancer Research

ISSN: 1465-542X

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