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Fig. 4 | Breast Cancer Research

Fig. 4

From: Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers

Fig. 4

In vivo effects of human epidermal growth factor receptor 3 (HER3) vaccine-induced antibody (HER3-VIA) on BT474M1 human breast tumor xenografts. a The experiment schema is shown. Tumor cells were implanted into SCID mice on day 0 and then HER3-VIA or control green fluorescence protein (GFP)-VIA was transferred via tail vein injection on day 14–33. b HER3-VIA retarded the growth of established BT474M1 breast cancers: *p < 0.001). c Immunohistochemical analysis of HER3 protein expression in excised tumors following HER3-VIA administration. d Western blot analysis of excised tumors probing for downstream signaling intermediaries of HER3 activation

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Breast Cancer Research

ISSN: 1465-542X

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