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Fig. 10 | Breast Cancer Research

Fig. 10

From: NOTCH3 expression is linked to breast cancer seeding and distant metastasis

Fig. 10

Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) analysis of claudin-low triple-negative breast cancer (TNBC) patients. The claudin-low subgroup analyzed in the METABRIC study represented a cluster of 125 patients characterized by 112 TNBC and 13 ER−/PR−/HER2+ specimens, and the average of age at diagnosis was 56.9 years. NOTCH3 alterations characterized by messenger RNA upregulation and/or copy number variations were detected in 8 of 117 cases (6 TNBC and 2 ER−/PR−/HER2+). Cases of death involved 6 patients with aberrant NOTCH3 expression and 46 patients without NOTCH3 alterations. Survival analysis showed that NOTCH3 expression was significantly associated with decreased overall survival (p = 0.0145)

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