The added value of mammography in different age-groups of women with and without BRCA mutation screened with breast MRI

Table 2 Population and breast cancer characteristics in the cohort

	Age < 40 years	Age 40–50 years	Age 50–60 years	Age ≥ 60 years	Overall	p value^a
Women (N)
BRCA	388	258	182	75	903	<0.001
Others	329	504	482	273	1588	0.014
Overall	717	762	664	348	2491	<0.001
Exams (N)
BRCA	1113	737	568	190	2608	<0.001
Others	716	1313	1265	651	3945	0.046
Overall	1829	2050	1833	841	6553	<0.001
BC (N)
Mammography	13	13	25	15	66	0.253
Mammography only	1	2	8	2	13	0.202
MRI	25	30	37	20	112	0.697
MRI only	13	19	20	7	59	0.254
Overall	26	32	45	22	125	0.963
Invasive tumor (N)
Mammography	13	9	16	12	50	0.771
Mammography only	1	0	4	0	5	0.822
MRI	24	25	30	18	97	0.496
MRI only	12	16	18	6	52	0.253
Overall	25	25	34	18	102	0.540
DCIS (N)
Mammography	0	4	9	3	16	0.073
Mammography only	0	2	5	1	8	0.281
MRI	1	5	7	2	15	0.036
MRI only	1	3	2	1	7	0.848
Overall	1	7	11	4	23	0.164
Tumor grade of all cancers (invasive and in situ) (N)
Grade 1
Mammography	1	1	4	1	7	0.536
Mammography only	0	0	1	0	1	0.655
MRI	3	4	5	5	17	0.384
MRI only	2	3	2	4	11	0.442
Grade 2
Mammography	1	5	7	4	17	0.171
Mammography only	0	1	2	1	4	0.317
MRI	3	10	17	6	36	0.170
MRI only	2	6	12	3	23	0.335
Grade 3
Mammography	11	7	11	6	35	0.339
Mammography only	1	1	2	1	5	0.822
MRI	17	15	15	5	52	0.010
MRI only	7	9	6	0	22	0.009
Missing	2	1	3	4	10	0.197
FPR (N)
Mammography	63	75	55	22	215	<0.001
Mammography only	22	38	28	15	103	0.115
MRI	159	143	72	25	399	<0.001
MRI only	118	106	45	18	287	<0.001
Overall	181	181	100	40	502	<0.001
FPB (N)
Mammography	35	46	32	9	122	<0.001
Mammography only	6	15	11	3	35	0.258
MRI	114	113	51	18	296	<0.001
MRI only	85	82	30	12	209	<0.001
Overall	120	128	62	21	331	<0.001

BC breast cancer (invasive cancer and ductal carcinoma in situ (DCIS)), MRI magnetic resonance imaging, FPR false positive recall, FPB false positive biopsy
^aChi-square test for trend was performed for the fraction of the overall population