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Fig. 6 | Breast Cancer Research

Fig. 6

From: Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth

Fig. 6

The tricho-rhino-phalangeal syndrome 1 (TRPSI)-ubiquitin-specific protease 4 (USP4)-histone deacetylase 2 (HDAC2) regulatory axis confers growth in cancer cells in vitro and in xenografted tumors in vivo. a MCF7 shows decreased cell viability upon silencing of TRPS1 and additional overexpression of HDAC2 restored cell viability. b MCF7 shows decreased cell viability upon silencing of USP4 and additional overexpression of HDAC2 restored cell viability. c Xenografted tumor growth curves (left), xenografted tumor weight (right). d Representative xenografted tumors from mouse models. e Representative western blot data of selected xenografted tumors show TRPS1 and myc-HDAC2 protein levels. f A working model of the current study. The t test was used for statistic quantifications: *p < 0.05, **p < 0.01, ***p < 0.001, respectively. siRNA, small interfering RNA

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Breast Cancer Research

ISSN: 1465-542X

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