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Fig. 4 | Breast Cancer Research

Fig. 4

From: Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth

Fig. 4

Tricho-rhino-phalangeal syndrome 1 (TRPS1) transcription factor regulates the transcription repressive activity of histone deacetylase 2 (HDAC2). a, b MCF7 shows increased H4K16ac level upon silencing of TRPS1, and overexpression of HDAC2 restored H4K16ac level. c, d MCF7 shows increased H4K16ac level upon silencing USP4, and overexpression of HDAC2 restored H4K16ac level. e–i Effects of TRPS1 and its truncation mutants over the transcriptional repression activity of HDAC2. The t test was used for statistical analysis: *p < 0.05; ns, not significant. Ab, antibody; siRNA, small interfering RNA; USP4, ubiquitin-specific protease 4

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Breast Cancer Research

ISSN: 1465-542X

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