| |
Premenopausal womena
|
Postmenopausal womenb
|
|---|
|
Case/control
|
OR
|
95% CI
|
Case/control
|
OR
|
95% CI
|
|---|
|
Multiple model stratified by BMI tertiles
|
|
Tertile 1 (BMI < 27.88)
|
67/47
| | |
145/166
| | |
|
TT3c
| |
0.02
|
0.003–0.09
| |
0.18
|
0.11–0.28
|
|
TT4c
| |
11.97
|
3.43–41.80
| |
2.62
|
1.67–4.09
|
|
Tertile 2 (BMI 27.88–32.05)
|
35/48
| | |
106/168
| | |
|
TT3c
| |
0.04
|
0.0 –0.16
| |
0.15
|
0.09–0.25
|
|
TT4c
| |
8.34
|
2.03–34.24
| |
3.03
|
1.83–5.02
|
|
Tertile 3 (BMI ≥ 32.06)
|
26/47
| | |
131/164
| | |
|
TT3c
| |
0.01
|
0.0004–0.08
| |
0.10
|
0.06–0.18
|
|
TT4c
| |
2.23
|
0.39–12.66
| |
3.52
|
2.15–5.75
|
|
p value for interaction between TT4 and BMI tertiles
| |
0.22
| | |
0.059
|
|
p value for interaction between TT3 and BMI tertiles
| |
0.12
| | |
0.34
|
- CAMA study Risk factors for breast cancer in Mexico: mammographic patterns, peptide C, and growth factors, a multicenter study, BMI body mass index, TT3 total triiodothyroxine, TT4 total thyroxine
- aLogistic regression model in premenopausal women: dependent variable, breast cancer (yes/no); independent variables, TT3 (nmol/L) and TT4 (nmol/L); potential confounders, age (years), city of residence (Mexico City (reference category) Veracruz and Monterrey), health institution (IMSS: Mexican Social Security Institute (reference category); ISSSTE: Institute of Security and Social Services of State Workers; SS: Ministry of Health), daily total consumption of calories (Kcal). Models are presented by each tertile of BMI. Hormone concentrations and calorie consumption were standardized to allow interpretation of the odds of breast cancer development per increment of standard deviation, Z = (x-μ)/σ
- bLogistic regression model in postmenopausal women: dependent variable, breast cancer (yes/no); independent variables, TT3 (nmol/L) and TT4 (nmol/L); potential confounders: age (years), city of residence (Mexico City (reference category) Veracruz and Monterrey), health institution (IMSS: Mexican Social Security Institute (reference category); ISSSTE: Institute of Security and Social Services of State Workers; SS: Ministry of Health), thyroid stimulating hormone (continuous), parity (continuous), consumed on average one or more alcoholic drinks a month for a year (yes/no) and smoked at least 100 cigarettes in her lifetime (yes/no) and indigenous ancestry (continuous). Models are presented by each tertile of BMI. Hormone concentrations and calorie consumption were standardized to allow interpretation of the odds of breast cancer development per increment of standard deviation, Z = (x-μ)/σ
- cTT3 (mean 1.7 SD 0.5); TT4 (mean 103.4 SD 27.3)
