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Table 5 Association between thyroid function tests and breast cancer modified by obesity in the CAMA study, Mexico, 2004–2007

From: Thyroid hormones and breast cancer association according to menopausal status and body mass index

  Premenopausal womena Postmenopausal womenb
Case/control OR 95% CI Case/control OR 95% CI
Multiple model stratified by BMI tertiles
 Tertile 1 (BMI < 27.88) 67/47    145/166   
  TT3c   0.02 0.003–0.09   0.18 0.11–0.28
  TT4c   11.97 3.43–41.80   2.62 1.67–4.09
 Tertile 2 (BMI 27.88–32.05) 35/48    106/168   
  TT3c   0.04 0.0 –0.16   0.15 0.09–0.25
  TT4c   8.34 2.03–34.24   3.03 1.83–5.02
 Tertile 3 (BMI ≥ 32.06) 26/47    131/164   
  TT3c   0.01 0.0004–0.08   0.10 0.06–0.18
  TT4c   2.23 0.39–12.66   3.52 2.15–5.75
p value for interaction between TT4 and BMI tertiles   0.22    0.059
p value for interaction between TT3 and BMI tertiles   0.12    0.34
  1. CAMA study Risk factors for breast cancer in Mexico: mammographic patterns, peptide C, and growth factors, a multicenter study, BMI body mass index, TT3 total triiodothyroxine, TT4 total thyroxine
  2. aLogistic regression model in premenopausal women: dependent variable, breast cancer (yes/no); independent variables, TT3 (nmol/L) and TT4 (nmol/L); potential confounders, age (years), city of residence (Mexico City (reference category) Veracruz and Monterrey), health institution (IMSS: Mexican Social Security Institute (reference category); ISSSTE: Institute of Security and Social Services of State Workers; SS: Ministry of Health), daily total consumption of calories (Kcal). Models are presented by each tertile of BMI. Hormone concentrations and calorie consumption were standardized to allow interpretation of the odds of breast cancer development per increment of standard deviation, Z = (x-μ)/σ
  3. bLogistic regression model in postmenopausal women: dependent variable, breast cancer (yes/no); independent variables, TT3 (nmol/L) and TT4 (nmol/L); potential confounders: age (years), city of residence (Mexico City (reference category) Veracruz and Monterrey), health institution (IMSS: Mexican Social Security Institute (reference category); ISSSTE: Institute of Security and Social Services of State Workers; SS: Ministry of Health), thyroid stimulating hormone (continuous), parity (continuous), consumed on average one or more alcoholic drinks a month for a year (yes/no) and smoked at least 100 cigarettes in her lifetime (yes/no) and indigenous ancestry (continuous). Models are presented by each tertile of BMI. Hormone concentrations and calorie consumption were standardized to allow interpretation of the odds of breast cancer development per increment of standard deviation, Z = (x-μ)/σ
  4. cTT3 (mean 1.7 SD 0.5); TT4 (mean 103.4 SD 27.3)