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Table 4 Associations between thyroid function tests and breast cancer adjusted by BMI in the CAMA study, Mexico, 2004–2007

From: Thyroid hormones and breast cancer association according to menopausal status and body mass index

  Premenopausal womena Postmenopausal womenb
case/control OR 95% CI case/control OR 95% CI
TT3c 128/142 0.03 0.01–0.07 382/498 0.17 0.13–0.22
TT4c   5.98 3.01–11.90   2.81 2.17–3.65
BMI
 Tertile 1 (BMI < 27.88) 67/47 1.00   145/166 1.00  
 Tertile 2 (BMI 27.88–32.05) 35/48 0.56 0.23–1.37 106/168 0.98 0.63–1.52
 Tertile 3 (BMI ≥ 32.06) 26/47 0.28 0.11–0.75 131/164 1.16 0.75–1.80
  1. CAMA study Risk factors for breast cancer in Mexico: mammographic patterns, C peptide, and growth factors, a multicenter study. TT3 total triiodothyroxine, TT4 total thyroxine, BMI body mass index
  2. aLogistic regression model in premenopausal women: dependent variable, breast cancer (yes/no); independent variables, TT3 (nmol/L) and TT4 (nmol/L); potential confounders, age (years), city of residence (Mexico City (reference category), Veracruz and Monterrey), health institution (IMSS: Mexican Social Security Institute (reference category); ISSSTE: Institute of Security and Social Services of State Workers; SS: Ministry of Health), daily total consumption of calories (Kcal) and BMI (tertiles). Hormone concentrations and calorie consumption were standardized to allow interpretation of the odds of breast cancer development per increment of standard deviation, Z = (x-μ)/σ
  3. bLogistic model in postmenopausal women: dependent variable, breast cancer (yes/no); independent variables, TT3 (nmol/L) and TT4 (nmol/L); potential confounders: age (years), city of residence (Mexico City (reference category), Veracruz and Monterrey), health institution (IMSS: Mexican Social Security Institute (reference category); ISSSTE: Institute of Security and Social Services of State Workers; SS: Ministry of Health), thyroid stimulating hormone (continuous), parity (continuous), consumed on average one or more alcoholic drinks a month for a year (yes/no) and smoked at least 100 cigarettes in her lifetime (yes/no), indigenous ancestry (continuous) and BMI (tertiles). Hormone concentrations and calorie consumption were standardized to allow interpretation of the odds of breast cancer development per increment of standard deviation, Z = (x-μ)/σ
  4. cTT3 (mean 1.7 SD 0.5); TT4 (mean 103.4 SD 27.3)