Study | Study arms | Mean age (SD) (years) | Sample size, n; drop out, n (%) | Sex hormone outcomes | Methods for sex hormone evaluation | Intervention period |
---|---|---|---|---|---|---|
SHAPE-2 [18], 2015, The Netherlands | Ex + D | 59.5 (4.9) | 98; 9 (9%) | Total estradiol, estrone, free estradiol, total testosterone, free testosterone, SHBG, androstenedione | Determined by liquid chromatography-mass spectrometry (LC-MC). SHBG by double-antibody radioimmunoassay (RIA) kitsb | 16 weeksa |
D | 60.5 (4.6) | 97; 6 (6%) | ||||
C | 60.0 (4.9) | 48; 3 (6%) | ||||
NEW trial [17], 2012, United States | Ex + D | 58.0 (4.4) | 117; 9 (8%) | Total estradiol, estrone, free estradiol, total testosterone, free testosterone, SHBG, androstenedione | Quantified by RIA after organic solvent extraction and Celite column partition chromatography. SHBG via chemiluminescent immunometric assay using Immulite Analyzerb | 6Â months, 12Â months |
Ex | 58.1 (5.0) | 117; 11 (9%) | ||||
D | 58.1 (5.9) | 118; 13 (11%) | ||||
C | 57.4 (4.4) | 87; 7 (8%) | ||||
ALPHA trial [24], 2010, Canada | Ex | 61.2 (5.4) | 160; 6 (4%) | Total estradiol, estrone, free estradiol, total testosterone, free testosterone, SHBG, androstenedione | Quantified by RIA after organic solvent extraction and Celite column partition chromatography. SHBG via immunometric assay using Immulite Analyzerb | 6Â months, 12Â months |
C | 60.6 (5.7) | 160; 6 (4%) | ||||
SHAPE-1, 2009 [3], The Netherlands | Ex | 58.9 (4.6) | 96; 1 (1%) | Total estradiol, estrone, free estradiol, total testosterone, free testosterone, SHBG, androstenedione | Double-antibody RIA kits were used for determining sex hormones, also for SHBGb | 4Â months, 12Â months |
C | 58.4 (4.2) | 93; 5 (5%) | ||||
Orsatti et al. [25], 2008, Brazil | Ex | 57.8 (8.0) | 27; 6 (22%) | Total testosterone, total estradiol | Measured by the Immulite System, automated immunoassay. | 16Â weeks |
C | 59.3 (6.2) | 23; 1 (4%) | ||||
Ex | 60.7 (6.7) | 87; 3 (3%) | Total estradiol, estrone, free estradiol, total testosterone, free testosterone, SHBG, androstenedione | Quantified by RIA after organic solvent extraction and Celite column partition chromatography. SHBG via immunometric assay using Immulite Analyzerb | 12Â months | |
C | 60.6 (6.8) | 86; 0 |