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Fig. 3 | Breast Cancer Research

Fig. 3

From: Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer

Fig. 3

Depletion of the PC inhibits in vitro cell growth. Two different shRNA sequences targeting PC (shPC25 and shPC28) were stably expressed in the 4 T1 cells and cellular viability was assessed under two-dimensional (a and c) and three-dimensional (b and d) culture conditions containing high (4.5 mg/ml; a and b) or low (1 mg/ml; c and d) amounts of glucose. Data are the mean ± SE of the three separate experiments completed in triplicate resulting in the indicated P values

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