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Table 5 Performance of miRNAs and their combinations to predict relapse in patients with early breast cancer

From: Circulating microRNAs in the early prediction of disease recurrence in primary breast cancer

Potential predictors Cutoff value Sensitivity (%) Specificity (%) AUC (95% CI) p
Early breast cancer
 miR-21 0.98 71.4 63.9 0.685 (0.592–0.777) < 0.001
 miR-23b 1.35 38.8 83.3 0.614 (0.512–0.716) 0.029
 miR-190 2.36 75.6 45.2 0.636 (0.534–0.738) 0.013
 miR-200b 1.72 51.0 72.3 0.597 (0.498–0.696) 0.063
 miR-200c 1.15 75.5 61.0 0.678 (0.586–0.769) < 0.001
 Three miRNAS (miR-21, miR-23b, miR-190) 0.39 80 65.3 0.765 (0.673–0.850) < 0.001
 Lymph nodes and grade 0.29 83 46.7 0.709 (0.614–0.804) < 0.001
 Three miRNAS plus lymph nodes and grade 0.41 89 76.2 0.873 (0.802–0.940) < 0.001
Late relapse (≥ 5 years)
 miR-200c and lymph nodes, grade and ER status 0.42 75 89 0.89 (0.812–0.972) < 0.001
  1. AUC area under the receiver operating curve, ER estrogen receptor