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Table 4 Univariate and multivariate analysis for DFS and OS in patients with early breast cancer

From: Circulating microRNAs in the early prediction of disease recurrence in primary breast cancer

 

Univariate analysis

 

DFS

OS

 

HR (95% CI)

p value

HR (95% CI)

p value

Tumor size, T2–3 vs T1

1.48 (0.832–2.633)

0.177

1.584 (0.623–4.026)

0.334

Lymph nodes, pos vs neg

2.288 (1.192–4.391)

0.013

3.553 (1.034–12.206)

0.044

Histology grade, III vs I/II

1.650 (0.910–3.003)

0.099

1.276 (0.501–3.251)

0.609

ER, neg vs pos

1.318 (0.731–2.375)

0.359

2.120 (0.857–5.244)

0.104

PR, neg vs pos

2.003 (1.131–3.549)

0.017

2.323 (0.940–5.743)

0.068

ER/PR, neg vs at least one pos

2.010 (1.080–3.741)

0.028

3.324 (1.329–8.314)

0.01

Her2 pos vs neg

1.649 (0.771–3.525)

0.197

1.474 (0.429–5.065)

0.538

miR-21 high vs low

2.896 (1.556–5.390)

<0.001

2.884 (1.038–8.013)

0.042

miR-23b high vs low

1.624 (0.903–2.919)

0.105

1.630 (0.629–4.227)

0.315

miR-190 low vs high

1.342 (0.749–2.405)

0.322

2.511 (0.877–7.186)

0.086

miR-200b high vs low

1.460 (0.821–2.599)

0.198

1.034 (0.417–2.565)

0.942

miR-200c high vs low

2.287 (1.258–4.156)

0.007

1.637 (0.640–4.184)

0.304

Both miR-21/mir-200c high vs others

2.360 (1.346–4.135)

0.003

2.225 (0.902–5.489)

0.082

 

Multivariate analysis

 

DFS

OS

 

HR (95% CI)

p value

HR (95% CI)

p value

Lymph nodes, pos vs neg

2.202 (1.138–4.260)

0.019

4.006 (1.151–13.935)

0.029

ER/PR, neg vs at least one pos

2.275 (1.202–4.305)

0.012

3.668 (1.457–9.233)

0.006

miR-21 high vs low

4.557 (1.685–12.869)

0.003

–

–

miR-200c high vs low

3.158 (1.074–9.288)

0.037

  
  1. DFS disease-free survival, OS overall survival, pos positive, neg negative, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2
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Breast Cancer Research

ISSN: 1465-542X

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