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Table 4 Univariate and multivariate analysis for DFS and OS in patients with early breast cancer

From: Circulating microRNAs in the early prediction of disease recurrence in primary breast cancer

  Univariate analysis
  DFS OS
  HR (95% CI) p value HR (95% CI) p value
Tumor size, T2–3 vs T1 1.48 (0.832–2.633) 0.177 1.584 (0.623–4.026) 0.334
Lymph nodes, pos vs neg 2.288 (1.192–4.391) 0.013 3.553 (1.034–12.206) 0.044
Histology grade, III vs I/II 1.650 (0.910–3.003) 0.099 1.276 (0.501–3.251) 0.609
ER, neg vs pos 1.318 (0.731–2.375) 0.359 2.120 (0.857–5.244) 0.104
PR, neg vs pos 2.003 (1.131–3.549) 0.017 2.323 (0.940–5.743) 0.068
ER/PR, neg vs at least one pos 2.010 (1.080–3.741) 0.028 3.324 (1.329–8.314) 0.01
Her2 pos vs neg 1.649 (0.771–3.525) 0.197 1.474 (0.429–5.065) 0.538
miR-21 high vs low 2.896 (1.556–5.390) <0.001 2.884 (1.038–8.013) 0.042
miR-23b high vs low 1.624 (0.903–2.919) 0.105 1.630 (0.629–4.227) 0.315
miR-190 low vs high 1.342 (0.749–2.405) 0.322 2.511 (0.877–7.186) 0.086
miR-200b high vs low 1.460 (0.821–2.599) 0.198 1.034 (0.417–2.565) 0.942
miR-200c high vs low 2.287 (1.258–4.156) 0.007 1.637 (0.640–4.184) 0.304
Both miR-21/mir-200c high vs others 2.360 (1.346–4.135) 0.003 2.225 (0.902–5.489) 0.082
  Multivariate analysis
  DFS OS
  HR (95% CI) p value HR (95% CI) p value
Lymph nodes, pos vs neg 2.202 (1.138–4.260) 0.019 4.006 (1.151–13.935) 0.029
ER/PR, neg vs at least one pos 2.275 (1.202–4.305) 0.012 3.668 (1.457–9.233) 0.006
miR-21 high vs low 4.557 (1.685–12.869) 0.003
miR-200c high vs low 3.158 (1.074–9.288) 0.037   
  1. DFS disease-free survival, OS overall survival, pos positive, neg negative, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2