Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression

Breast Cancer Research

Table 3 Estrogen promotes Brca1-deficient mammary tumor initiation and progression

Genotype	p18 ^-/- ;Brca1 ^MGKO - Donor A
number of tumor cell transplanted ^a	1 x10⁶/mouse
Treatment	Placebo	E2
Tumor incidence (7 weeks)	4/4 (100%)	4/4 (100%)
Tumor size (mm³)	426 ± 98	1294 ± 265^c
Tumor number with metastasis	0/4	1/4 ^d
Genotype	p16 ^-/- ;Brca1 ^MGKO - Donor B
number of tumor cell transplanted ^b	6x10⁴/mouse
T reatment	Placebo	E2
Tumor incidence (6 weeks)	4/4 (100%)	4/4 (100%)
Tumor size (mm³)	50 ± 22	785 ± 452 ^c

^aCultured tumor cells were used
^bFACS-sorted Lin- tumor cells were used
^cA statistical significance from E2-and Placebo-treated groups by two tailed t test
^dA tumor metastasized to the lung and liver. No statistical significance was detected in tumor metastasis between E2- and placebo-treated groups by two tailed Fisher Exact test

ISSN: 1465-542X