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Table 3 Estrogen promotes Brca1-deficient mammary tumor initiation and progression

From: Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression

Genotype p18 -/- ;Brca1 MGKO - Donor A
number of tumor cell transplanted a 1 x106/mouse  
Treatment Placebo E2
Tumor incidence (7 weeks) 4/4 (100%) 4/4 (100%)
Tumor size (mm3) 426 ± 98 1294 ± 265c
Tumor number with metastasis 0/4 1/4 d
Genotype p16 -/- ;Brca1 MGKO - Donor B
number of tumor cell transplanted b 6x104/mouse
T reatment Placebo E2
Tumor incidence (6 weeks) 4/4 (100%) 4/4 (100%)
Tumor size (mm3) 50 ± 22 785 ± 452 c
  1. aCultured tumor cells were used
  2. bFACS-sorted Lin- tumor cells were used
  3. cA statistical significance from E2-and Placebo-treated groups by two tailed t test
  4. dA tumor metastasized to the lung and liver. No statistical significance was detected in tumor metastasis between E2- and placebo-treated groups by two tailed Fisher Exact test