Skip to main content

Table 1 Deletion of Brca1 in p18 and p16 null epithelia induces estrogen receptor (ER)-negative mammary tumors

From: Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression

Genotypea Mammary tumor number ERα + tumor number % ERα + cells/tumor Ck5/Ck14+ tumor number % Ck5/Ck14+ cells/tumor
Wild-type 0/9     
p18 −/− 7/15 (47%) 5/7 (71%) 2% - 50% 2/7 (29%) 2%, 5%
Brca1 MGKO b 1/13 (8%) 0/1   1/1(100%)c 20%
p18 −/− ;Brca1 MGKO 11/15 (73%) 2/11 (18%)d 2%, 5% 10/11 (82%)d 2–80%
p16 −/− 0/20     
p16 −/− ;Brca1 MGKO 6/10 (60%) 0/6e   6/6(100%)e 2%-80%
  1. aAll mice were in the Balb/c-B6 mixed background and were at the age of 12–26 months
  2. bBrca1MGKO, Brca1f/f;MMTV-Cre or Brca1f/−;MMTV-Cre
  3. cA mouse with tumor harboring p53 mutation was 24 months of age
  4. dSignificance for p18−/−;Brca1MGKO and p18−/− tumors analyzed by the two-tailed Fisher’s exact test
  5. eSignificance for p16−/−;Brca1MGKO and p18−/− tumors analyzed by the two-tailed Fisher’s exact test