Skip to main content
Fig. 3 | Breast Cancer Research

Fig. 3

From: Syndecan-1 induction in lung microenvironment supports the establishment of breast tumor metastases

Fig. 3

Syndecan-1 (Sdc1) expression in the metastatic microenvironment. Tissue sections are from tail-vein-injected 4T1 cells in Sdc1+/+ mouse (a-f) or human (g, h) mammary carcinoma lung metastases unless stated otherwise and were labeled with antibodies to Sdc1 and cell lineage markers as indicated. a Sdc1 (green) and fibroblast marker ER-TR7 (red). b Normal lung tissue labeled for Sdc1 (green) and fibroblast marker ER-TR7 (red). c Sdc1 (green) and endothelial cell marker CD31 (red). d) Sdc1 (green) and myofibroblast/smooth muscle/pericyte marker alpha smooth muscle actin (αSMA) (red). e Sdc1 (green) and leucocyte marker CD45 (red). f Sdc1 (green) and macrophage marker CD68 (red). g Human breast cancer metastasis to the lung labeled for Sdc1 (brown) and mesenchymal marker vimentin (Vim, magenta). Original magnification approximately × 400 for all images. Metastatic lesions are outlined with dashed lines. M, metastasis; S, stroma; V, vessel; DAPI, 4′,6-diamidino-2-phenylindole

Back to article page