Rank | CpG | Gene/ Location | 25(OH)D-methylation association, subcohort | 25(OH)D-methylation association, cases | Fisher combined p value | HR (95% CI) for methylation-breast cancer association | RHRs (95% CI)c | Interaction p value | ||
---|---|---|---|---|---|---|---|---|---|---|
Cofficientb | p value | Cofficientb | p value | |||||||
1 | cg08092930 | PPFIA1 | −0.03 | 1.3 × 10−5 | 0.02 | 0.04 | 8.5 × 10−6* | 1.01 (0.98–1.05) | 1.15 (1.06–1.24) | 6.3 × 10−4 |
2 | cg23761815 | SLC29A3 | −0.02 | 5.1 × 10−7 | − 0.01 | 0.03 | 2.7 × 10−7 | 1.13 (1.07–1.18) | 1.22 (1.08–1.38) | 0.002 |
3 | cg13243168 | SMARCD2 | −0.02 | 2.9 × 10−7 | − 7 × 10−4 | 0.87 | 4.0 × 10−6 | 1.05 (0.98–0.91) | 1.29 (1.09–1.51) | 0.002 |
4 | cg15544721 | PPP1R9A | −0.01 | 0.09 | −0.03 | 6.4 × 10−6 | 8.8 × 10−6 | 0.98 (0.94–1.03) | 0.87 (0.79–0.96) | 0.008 |
5 | cg11568290 | 5p15.1 | −0.02 | 1.4 × 10−4 | −0.01 | 0.004 | 7.7 × 10−6 | 1.15 (1.08–1.22) | 1.23 (1.05–1.44) | 0.009 |
6 | cg19420720 | P4HB | −0.01 | 0.002 | 0.02 | 2.3 × 10−4 | 8.1 × 10−6* | 1.01 (0.94–1.08) | 1.27 (1.06–1.52) | 0.01 |
7 | cg23839180 | FAM49A | −0.02 | 0.05 | −0.05 | 3.0 × 10−6 | 2.3 × 10−6 | 0.97 (0.94–1.03) | 0.92 (0.86–0.98) | 0.01 |
8 | cg15320474d | UBD | 0.02 | 2.8 × 10−6 | − 0.01 | 0.16 | 7.0 × 10−6* | 0.98 (0.83–1.04) | 0.87 (0.77–0.99) | 0.03 |
9 | cg24350360d | EPHX1 | −0.04 | 3.4 × 10−8 | 0.01 | 0.48 | 3.1 × 10−7* | 1.02 (0.99–1.05) | 1.08 (1.01–1.16) | 0.04 |
10 | cg22488164 | PLBD1 | −0.03 | 1.5 × 10−4 | −0.03 | 5.0 × 10−4 | 1.3 × 10−6 | 1.06 (1.02–1.10) | 0.93 (0.85–1.01) | 0.07 |
11 | cg10401362 | DNAJB6 | −0.02 | 1.0 × 10−6 | −0.01 | 0.27 | 4.4 × 10−6 | 1.02 (0.97–1.07) | 1.10 (0.98–1.24) | 0.10 |
12 | cg06177555 | SPN | −0.02 | 9.8 × 10−8 | −0.003 | 0.54 | 9.3 × 10−7 | 0.97 (0.91–1.03) | 1.12 (0.98–1.28) | 0.10 |
13 | cg11277126 | TRPC4AP | −0.02 | 7.7 × 10−5 | −0.02 | 4.8 × 10−4 | 6.7 × 10−7 | 1.04 (0.98–1.11) | 1.07 (0.92–1.24) | 0.39 |
14 | cg21527411 | GLYAT | 0.02 | 2.1 × 10−6 | −0.01 | 0.30 | 9.6 × 10−6* | 1.02 (0.97–1.07) | 0.95 (0.83–1.08) | 0.40 |
15 | cg09914444 | DMBX1 | 0.02 | 5.4 × 10−6 | −0.01 | 0.08 | 6.9 × 10−6* | 1.05 (1.01–1.10) | 0.96 (0.87–1.06) | 0.44 |
16 | cg23999318 | HIPK2 | −0.02 | 2.8 × 10−4 | −0.02 | 3.5 × 10−4 | 1.7 × 10−6 | 1.00 (0.94–1.05) | 1.00 (0.88–1.14) | 1.00 |