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Fig. 6 | Breast Cancer Research

Fig. 6

From: Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages

Fig. 6

Summary scheme of the identified paracrine signalling from breast cancer (BC) cells to macrophages. Briefly, breast cancer cells expressing high levels of inhibitor of differentiation 4 (ID4) protein produce vascular endothelial growth factor A (VEGFA) and other factors implicated in the induction of an angiogenic programme in neighbouring macrophages. In parallel to the induction of angiogenesis-related messenger RNAs, we observed a decrease of miR-15b/107 group members, with consequent release of the expression of its targets, as transcription factor hypoxia-inducible factor (HIF)-1A and granulin (GRN). TAM Tumour-associated macrophage

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Breast Cancer Research

ISSN: 1465-542X

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