Tumor subtypes | Training AUC (95% CI) | Testing AUC (95% CI) |
---|---|---|
Group 1 (HER2 subtype) | ||
 Her2 | 0.71 (0.66–0.75) | 0.78 (0.74–0.81) |
 Her2, tHb | 0.88 (0.85–0.91) | 0.88 (0.85–0.91) |
 Her2, tHb, ER | 0.91 (0.89–0/94) | 0.87 (0.84–0.90) |
 Her2, tHb, NS | 0.91 (0.88–0.94) | 0.85 (0.82–0.88) |
 Her2, tHb, %tHb_cyc1 | 0.89 (0.87–0.92) | 0.96 (0.95–0.98) |
 Her2, tHb, %tHb_cyc2 | 0.89 (0.86–0.91) | 0.94 (0.92–0.96) |
 Her2, tHb, %tHb_cyc3 | 0.96 (0.94–0/97) | 0.89 (0.86–0.92) |
 Her2, tHb, %tHb_cyc1, %tHb_cyc2 | 0.90 (0.87–0.93) | 0.97 (0.96–0.99) |
 Her2, tHb, %tHb_cyc1, %tHb_cyc3 | 0.96 (0.94–0.97) | 0.88 (0.85–0.91) |
 Her2, tHb, %tHb_cyc2, %tHb_cyc3 | 0.96 (0.94–0.98) | 0.88 (0.85–0.91) |
 Her2, tHb, %tHb_cyc1, %tHb_cyc2, %tHb_cyc3 | 0.96 (0.94–0.98) | 0.88 (0.86–0.92) |
Group 2 (ER subtype) | ||
 ER | 0.67 (0.63–0.72) | 0.55 (0.50–0.59) |
 ER, tHb | 0.81 (0.77–0.85) | 0.69 (0.64–0.73) |
 ER, tHb, NS | 0.83 (0.80–0.87) | 0.69 (0.65–0.73) |
 ER, tHb, %tHb_cyc1 | 0.85 (0.82–0.89) | 0.91 (0.88–0.93) |
 ER, tHb, %tHb_cyc2 | 0.86 (0.83–0.89) | 0.79 (0.75–0.83) |
 ER, tHb, %tHb_cyc3 | 0.97 (0.95–0.98) | 0.77 (0.73–0.81) |
 ER, tHb, %tHb_cyc1, %tHb_cyc2 | 0.88 (0.85–0.91) | 0.86 (0.83–0.89) |
 ER, tHb, %tHb_cyc1, %tHb_cyc3 | 0.96 (0.95–0.98) | 0.76 (0.73–0.80) |
 ER, tHb, %tHb_cyc2, %tHb_cyc3 | 0.97 (0.95–0.98) | 0.77 (0.73–0.81) |
Group 3 (TN subtype) | ||
 TN | 0.55 (0.51–0.56) | 0.46 (0.41–0.50) |
 TN, tHb | 0.77 (0.74–0.81) | 0.72 (0.68–0.76) |
 TN, tHb, NS | 0.81 (0.78–0.85) | 0.69 (0.65–0.75) |
 TN, tHb, %tHb_cyc1 | 0.84 (0.81–0.87) | 0.90 (0.87–0.93) |
 TN, tHb, %tHb_cyc2 | 0.85 (0.82–0.88) | 0.84 (0.81–0.88) |
 TN, tHb, %tHb_cyc3 | 0.96 (0.94–0.98) | 0.76 (0.72–0.80) |
 TN, tHb, %tHb_cyc1, %tHb_cyc2 | 0.85 (0.82–0.88) | 0.90 (0.87–0.93) |
 TN, tHb, %tHb_cyc1, %tHb_cyc3 | 0.96 (0.94–0.98) | 0.75 (0.71–0.79) |
 TN, tHb, %tHb_cyc2, %tHb_cyc3 | 0.96 (0.94–0.98) | 0.75 (0.71–0.79) |
Group 4 (tHb and %tHb, all patients) | ||
 tHb | 0.77 (0.73–0.81) | 0.75 (0.71–0.79) |
 tHb, %tHb_cyc1 | 0.83 (0.80–0.87) | 0.95 (0.93–0.97) |
 tHb, %tHb_cyc2 | 0.84 (0.80–0.86) | 0.87 (0.84–0.90) |
 tHb, %tHb_cyc3 | 0.94 (0.92–0.97) | 0.80 (0.76–0.84) |
 tHb, %tHb_cyc1, %tHb_cyc2 | 0.84 (0.81–0.88) | 0.92 (0.90–0.95) |
 tHb, %tHb_cyc1, %tHb_cyc2, %tHb_cyc3 | 0.94 (0.92–0.96) | 0.80 (0.76–0.84) |
%tHb_cyc1 | 0.79 (0.75–0.83) | 0.89 (0.86–0.92) |
%tHb_cyc2 | 0.83 (0.80–0.86) | 0.81 (0.78–0.85) |
%tHb_cyc3 | 0.94 (0.92–0.96) | 0.82 (0.78–0.85) |
%tHb_cyc1, %tHb_cyc2 | 0.82 (0.78–0.87) | 0.87 (0.83–0.90) |
%tHb_cyc1, %tHb_cyc2, %tHb_cyc3 | 0.94 (0.92–0.96) | 0.82 (0.79–0.86) |