TY - JOUR AU - Johnston, A. N. AU - Bu, W. AU - Hein, S. AU - Garcia, S. AU - Camacho, L. AU - Xue, L. AU - Qin, L. AU - Nagi, C. AU - Hilsenbeck, S. G. AU - Kapali, J. AU - Podsypanina, K. AU - Nangia, J. AU - Li, Y. PY - 2018 DA - 2018/05/19 TI - Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions JO - Breast Cancer Research SP - 42 VL - 20 IS - 1 AB - Psychiatric medications are widely prescribed in the USA. Many antipsychotics cause serum hyperprolactinemia as an adverse side effect; prolactin-Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) signaling both induces cell differentiation and suppresses apoptosis. It is controversial whether these antipsychotics increase breast cancer risk. SN - 1465-542X UR - https://doi.org/10.1186/s13058-018-0969-z DO - 10.1186/s13058-018-0969-z ID - Johnston2018 ER -