Assessing brain volume changes in older women with breast cancer receiving adjuvant chemotherapy: a brain magnetic resonance imaging pilot study

Table 4 Comparison of longitudinal volume changes in the chemotherapy subgroups and the healthy control (HC) group

	Non-TC (n = 9)	TC (n = 7)	HC (n = 14)	TC vs. non-TC, p	Non-TC vs. HC, p	TC vs. HC, p
Total white matter	0.04	3.25	0.90	0.46	0.67	0.24
Total gray matter	−0.56	−3.99*	− 0.99	0.04	0.75	0.05
Frontal lobe	−0.34	−0.32	− 0.27	0.91	0.68	0.80
Temporal lobe	0.04	−0.26*	0.08	0.02	0.70	0.004
Parietal lobe	−0.13	0.01	−0.08	0.26	0.64	0.42
Occipital lobe	0.04	−0.03	−0.02	0.40	0.38	0.92

The TC subgroup (n = 7) included the patients on the docetaxel and cyclophosphamide chemotherapy regimen. The non-TC subgroup (n = 9) included the patients on a chemotherapy regimen other than the TC regimen. *p < 0.01

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