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Table 4 Stages 1 and 2 and meta-analysis of rs9913477 and rs4969239 located in the primary transcript of miR-3065

From: A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women

SNP

Chromosome:Positiona

Effect/other allele

Stageb

Sample

size

EAF

OR (95% CI)

p

rs4969239

17:79010544

G/A

Stage 1

8350

0.08

1.35 (1.2–1.52)

1.40 × 10–6

Stage 2

3814

0.08

1.07 (0.83–1.39)

5.78 × 10–1

Meta-analysis

12,164

0.08

1.29 (1.16–1.44)

4.18 × 10–6

rs9913477

17:79015698

G/A

Stage 1

8350

0.06

1.44 (1.30–1.58)

3.15 × 10–7

Stage 2

3815

0.06

0.86 (0.62–1.18)

3.56 × 10–1

Meta-analysis

12,165

0.06

1.33 (1.17–1.51)

1.60 × 10–5

  1. CI, confidence interval; EAF, effect allele frequency; OR, odds ratio; SNP, single nucleotide polymorphism
  2. aHuman Genome GRCh37/hg19 assembly, NT_010783.15
  3. bStage 1 model: Additive genetic models were adjusted for age group (by ~ 10-year intervals), WCHS study site, geographic region of residence, DNA source, and ancestry (PCs 5, 6 and 8 associated with cancer trait, p < 0.1); Stage 2 model: Additive genetic models were adjusted for age group (by ~ 10-year intervals), DNA source, and ancestry (PCs 1); Meta-analysis was performed in METAL [67]; heterogeneity I2 = 88.1 for rs9913477 and 58.1 for rs4969239