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Table 4 Stages 1 and 2 and meta-analysis of rs9913477 and rs4969239 located in the primary transcript of miR-3065

From: A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women

SNP Chromosome:Positiona Effect/other allele Stageb Sample
size
EAF OR (95% CI) p
rs4969239 17:79010544 G/A Stage 1 8350 0.08 1.35 (1.2–1.52) 1.40 × 10–6
Stage 2 3814 0.08 1.07 (0.83–1.39) 5.78 × 10–1
Meta-analysis 12,164 0.08 1.29 (1.16–1.44) 4.18 × 10–6
rs9913477 17:79015698 G/A Stage 1 8350 0.06 1.44 (1.30–1.58) 3.15 × 10–7
Stage 2 3815 0.06 0.86 (0.62–1.18) 3.56 × 10–1
Meta-analysis 12,165 0.06 1.33 (1.17–1.51) 1.60 × 10–5
  1. CI, confidence interval; EAF, effect allele frequency; OR, odds ratio; SNP, single nucleotide polymorphism
  2. aHuman Genome GRCh37/hg19 assembly, NT_010783.15
  3. bStage 1 model: Additive genetic models were adjusted for age group (by ~ 10-year intervals), WCHS study site, geographic region of residence, DNA source, and ancestry (PCs 5, 6 and 8 associated with cancer trait, p < 0.1); Stage 2 model: Additive genetic models were adjusted for age group (by ~ 10-year intervals), DNA source, and ancestry (PCs 1); Meta-analysis was performed in METAL [67]; heterogeneity I2 = 88.1 for rs9913477 and 58.1 for rs4969239