A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women

Table 2 Association of the top seven miRNA SNPs with p < 5 × 10⁻⁶ and breast cancer risk

SNP	Chromosome:position^a	Effect/other allele	EAF	OR (95% CI)	p ^b	FDR p^c	INFO (r²)
rs142882938	17:79010031	C/CT	0.06	1.45 (1.24–1.70)	5.9 × 10^–7	0.03	0.97
rs4969239^d	17:79010544	G/A	0.08	1.35 (1.20–1.52)	1.4 × 10^–6	0.06	–
rs28585511	17:79010609	T/A	0.06	1.45 (1.26–1.66)	5.8 × 10^–7	0.03	0.98
rs4969351	17:79011141	A/G	0.08	1.35 (1.20–1.52)	3.4 × 10^–6	0.11	0.99
rs9913477	17:79015698	G/A	0.06	1.44 (1.26–1.65)	3.2 × 10^–7	0.03	0.99
rs7502931	17:79018677	G/A	0.06	1.44 (1.26–1.65)	3.4 × 10^–7	0.03	0.99
rs4969366^d	17:79026572	G/A	0.05	1.45 (1.24–1.70)	1.5 × 10^–6	0.06	–

The seven single nucleotide polymorphisms (SNPs) are intronic to BAIAP2 and located in the primary transcript of miR-3065
Significant FDR results are shown in bold
CI, confidence interval; EAF, effect allele frequency; FDR, false discovery rate; INFO, imputation quality score; OR, odds ratio
^aHuman Genome GRCh37/hg19 assembly, NT_010783.15
^bAdditive genetic models were adjusted for age group (by ~ 10-year intervals), study site, geographic region of residence, DNA source, and ancestry (PCs 5, 6, and 8 associated with cancer trait, p < 0.1). Sample size: 3663 cases and 4687 controls
^cAdjustment for multiple comparisons using the FDR
^dGenotyped SNPs, with the other SNPs having been imputed to 1000 Genome Project data

ISSN: 1465-542X