Skip to main content

Table 2 Association of the top seven miRNA SNPs with p < 5 × 10−6 and breast cancer risk

From: A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women

SNP Chromosome:positiona Effect/other allele EAF OR (95% CI) p b FDR pc INFO (r2)
rs142882938 17:79010031 C/CT 0.06 1.45 (1.24–1.70) 5.9 × 10–7 0.03 0.97
rs4969239d 17:79010544 G/A 0.08 1.35 (1.20–1.52) 1.4 × 10–6 0.06
rs28585511 17:79010609 T/A 0.06 1.45 (1.26–1.66) 5.8 × 10–7 0.03 0.98
rs4969351 17:79011141 A/G 0.08 1.35 (1.20–1.52) 3.4 × 10–6 0.11 0.99
rs9913477 17:79015698 G/A 0.06 1.44 (1.26–1.65) 3.2 × 10–7 0.03 0.99
rs7502931 17:79018677 G/A 0.06 1.44 (1.26–1.65) 3.4 × 10–7 0.03 0.99
rs4969366d 17:79026572 G/A 0.05 1.45 (1.24–1.70) 1.5 × 10–6 0.06
  1. The seven single nucleotide polymorphisms (SNPs) are intronic to BAIAP2 and located in the primary transcript of miR-3065
  2. Significant FDR results are shown in bold
  3. CI, confidence interval; EAF, effect allele frequency; FDR, false discovery rate; INFO, imputation quality score; OR, odds ratio
  4. aHuman Genome GRCh37/hg19 assembly, NT_010783.15
  5. bAdditive genetic models were adjusted for age group (by ~ 10-year intervals), study site, geographic region of residence, DNA source, and ancestry (PCs 5, 6, and 8 associated with cancer trait, p < 0.1). Sample size: 3663 cases and 4687 controls
  6. cAdjustment for multiple comparisons using the FDR
  7. dGenotyped SNPs, with the other SNPs having been imputed to 1000 Genome Project data