Fig. 6From: A novel neuregulin – jagged1 paracrine loop in breast cancer transendothelial migrationProposed model. Neuregulin (NRG1) produced by tumor cells binds to ErbB3 on macrophages, stimulating production of the Notch ligand jagged 1 (JAG1). JAG1 in turn binds to Notch on tumor cells, stimulating intravasationBack to article page