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Table 3 Multivariable analysis of patient demographics and characteristics comparing overall survival

From: Practice patterns and outcomes for patients with node-negative hormone receptor-positive breast cancer and intermediate 21-gene Recurrence Scores

 

Adjusted hazard ratio

95% confidence interval

p value

Facility type

 Community cancer program

2.44

1.26–4.75

0.01

 Comprehensive community cancer program

1.54

0.92–2.58

0.10

 Academic/research program

REF

  

 Other

1.45

0.66–3.17

0.36

Age category (years)

 < 40

REF

  

 40–49

1.41

0.16–12.31

0.76

 50–59

2.36

0.29–19.42

0.43

 60–69

2.56

0.31–21.28

0.38

 70–79

5.02

0.58–43.63

0.14

 80+

8.40

0.89–89.81

0.08

Race/ethnicity

 Non-Hispanic White

REF

  

 Non-Hispanic Black

1.99

1.12–3.52

0.02

 Hispanic

0.51

0.12–2.11

0.36

 Non-Hispanic Asian/Pacific

0.86

0.21–3.56

0.84

 Other

0.46

0.14–1.44

0.18

Primary payer

 Not insured

1.78

0.43–7.41

0.43

 Private insurance

REF

  

 Medicaid

2.21

1.01–4.80

0.05

 Medicare

1.38

0.77–2.48

0.28

 Other

2.76

0.97–7.87

0.06

Urban/rural

 Metro counties

REF

  

 Urban counties

1.04

0.60–1.82

0.89

 Rural counties

1.78

0.55–5.76

0.33

 Unknown

0.76

0.18–3.14

0.70

Charlson–Deyo score

 0

REF

  

 1

3.00

1.92–4.67

< 0.001

 2

6.74

3.40–13.34

< 0.001

Grade

 Well differentiated, differentiated, NOS

REF

  

 Moderately differentiated, moderately well differentiated, intermediate differentiation

1.13

0.69–1.87

0.63

 Poorly differentiated

2.00

1.10–3.63

0.02

AJCC pathologic stage

 T1C

REF

  

 T2

2.17

1.45–3.25

< 0.001

Lymphovascular invasion

 Not present

REF

  

 Present

1.23

0.70–2.16

0.48

Type of surgery

 Breast conservation

REF

  

 Mastectomy

0.45

0.20–1.02

0.06

Radiation therapy

 None

REF

  

 Beam radiation

0.38

0.17–0.83

0.01

  1. AJCC American Joint Committee on Cancer, NOS not otherwise specified, REF reference