Skip to main content

Table 4 Associations between mitochondrial DNA integrity (ND4/ND1 divided by ND1/nuclear genome) and breast cancer risk

From: Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Stratum mtDNA integritya Controls Cases OR 95% CI p value
Overall Quartile 1 (0.34–0.90) 129 152 Reference   
  Quartile 2 (0.90–1.00) 126 102 1.06 (0.68–1.66) 0.79
  Quartile 3 (1.00–1.11) 133 142 1.56 (0.95–2.56) 0.08
  Quartile 4 (1.11–2.59) 130 142 1.20 (0.69–2.08) 0.52
  Continuous variable 519 539 1.07 (0.75–1.52) 0.73
ER+ Quartile 1 (0.34–0.90) 129 20 Reference
  Quartile 2 (0.90–1.00) 126 50 1.61 (0.78–3.35) 0.20
  Quartile 3 (1.00–1.11) 133 79 2.59 (1.19–5.66) 0.02
  Quartile 4 (1.11–2.59) 130 89 2.47 (1.05–5.80) 0.04
  Continuous variable 519 238 1.54 (0.87–2.72) 0.14
ER− Quartile 1 (0.34–0.90) 129 128 Reference
  Quartile 2 (0.90–1.00) 126 40 0.98 (0.55–1.74) 0.94
  Quartile 3 (1.00–1.11) 133 47 1.22 (0.62–2.39) 0.56
  Quartile 4 (1.11–2.59) 130 41 0.96 (0.46–2.00) 0.92
  Continuous variable 519 256 0.99 (0.63–1.54) 0.95
  1. ER Estrogen receptor, mtDNA Mitochondrial DNA
  2. aAnalyses are adjusted for age, body mass index, smoking, center of origin, and plate
\