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Table 3 Associations between mitochondrial DNA copy number and breast cancer risk

From: Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Stratum mtDNA copy numbera Controls Cases OR 95% CI p value
Overall Quartile 1 (0.11–0.21) 132 117 Reference
  Quartile 2 (0.21–0.29) 132 148 1.48 (1.00–2.20) 5.24E-02
  Quartile 3 (0.29–0.47) 125 122 1.30 (0.81–2.11) 2.77E-01
  Quartile 4 (0.47–1.52) 133 161 0.93 (0.53–1.66) 8.18E-01
  Continuous variable 522 548 0.97 (0.66–1.42) 8.75E-01
ER+ Quartile 1 (0.11–0.21) 132 68 Reference
  Quartile 2 (0.21–0.29) 132 94 1.43 (0.85–2.39) 1.77E-01
  Quartile 3 (0.29–0.47) 125 65 1.23 (0.65–2.32) 5.22E-01
  Quartile 4 (0.47–1.52) 133 18 0.46 (0.18–1.13) 8.95E-02
  Continuous variable 522 245 0.67 (0.36–1.25) 2.11E-01
ER− Quartile 1 (0.11–0.21) 132 41 Reference
  Quartile 2 (0.21–0.29) 132 42 1.33 (0.74–2.38) 3.43E-01
  Quartile 3 (0.29–0.47) 125 35 0.90 (0.43–1.91) 7.91E-01
  Quartile 4 (0.47–1.52) 133 140 0.94 (0.44–2.02) 8.81E-01
  Continuous variable 522 258 1.04 (0.64–1.69) 8.79E-01
  1. ER Estrogen receptor, mtDNA Mitochondrial DNA
  2. aAnalyses are adjusted for age, body mass index, smoking, center of origin, and plate
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