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Table 3 Associations between mitochondrial DNA copy number and breast cancer risk

From: Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Stratum

mtDNA copy numbera

Controls

Cases

OR

95% CI

p value

Overall

Quartile 1 (0.11–0.21)

132

117

Reference

 

Quartile 2 (0.21–0.29)

132

148

1.48

(1.00–2.20)

5.24E-02

 

Quartile 3 (0.29–0.47)

125

122

1.30

(0.81–2.11)

2.77E-01

 

Quartile 4 (0.47–1.52)

133

161

0.93

(0.53–1.66)

8.18E-01

 

Continuous variable

522

548

0.97

(0.66–1.42)

8.75E-01

ER+

Quartile 1 (0.11–0.21)

132

68

Reference

 

Quartile 2 (0.21–0.29)

132

94

1.43

(0.85–2.39)

1.77E-01

 

Quartile 3 (0.29–0.47)

125

65

1.23

(0.65–2.32)

5.22E-01

 

Quartile 4 (0.47–1.52)

133

18

0.46

(0.18–1.13)

8.95E-02

 

Continuous variable

522

245

0.67

(0.36–1.25)

2.11E-01

ER−

Quartile 1 (0.11–0.21)

132

41

Reference

 

Quartile 2 (0.21–0.29)

132

42

1.33

(0.74–2.38)

3.43E-01

 

Quartile 3 (0.29–0.47)

125

35

0.90

(0.43–1.91)

7.91E-01

 

Quartile 4 (0.47–1.52)

133

140

0.94

(0.44–2.02)

8.81E-01

 

Continuous variable

522

258

1.04

(0.64–1.69)

8.79E-01

  1. ER Estrogen receptor, mtDNA Mitochondrial DNA
  2. aAnalyses are adjusted for age, body mass index, smoking, center of origin, and plate