Skip to main content

Advertisement

Table 3 Associations of newly identified mammographic density loci with breast cancer risk, overall and stratified by estrogen receptor status

From: Common genetic variation and novel loci associated with volumetric mammographic density

       Karma BCAC
       Pooled MD analysis MAF Breast cancer overall Breast cancer ER− Breast cancer ER+
Locus Base pair Lead SNP Gene A1 A2 β (SE) P overall   OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
Percent dense volume
 10q25.3 115,248,851 rs2089176 HABP2 A G − 0.07 (0.01) 4.1 × 10− 9 0.36 0.98 (0.97–0.99) 0.01 1.00 (0.98–1.03) 0.70 0.97 (0.96–0.99) 5.3 × 10− 4
Absolute dense volume
 2q14.2 121,092,388 rs12468790 INHBB A G 0.08 (0.01) 2.1 × 10− 8 0.40 0.97 (0.96–0.98) 4.8 × 10− 6 0.93 (0.91–0.95) 1.5 × 10− 9 0.98 (0.96–0.99) 3.8 × 10− 3
 17q24.3 67,836,371 rs9302903 LINC01483 T C − 0.14 (0.02) 5.9 × 10− 9 0.09 0.96 (0.94–0.99) 1.1 × 10− 3 0.98 (0.94–1.02) 0.26 0.95 (0.93–0.98) 1.5 × 10− 4
  1. Abbreviations: BCAC Breast Cancer Association Consortium, SNP Single-nucleotide polymorphism, A1 Major allele, A2 Minor allele, MAF Minor allele frequency, ER− Estrogen receptor-negative, ER+ Estrogen receptor-positive
  2. MAF in BCAC as observed in genotyped control subjects (Europeans only). Gene refers to nearest gene