Table 3 Associations of newly identified mammographic density loci with breast cancer risk, overall and stratified by estrogen receptor status
From: Common genetic variation and novel loci associated with volumetric mammographic density
| Â | Â | Â | Â | Â | Â | Karma | BCAC | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  |  |  |  |  |  | Pooled MD analysis | MAF | Breast cancer overall | Breast cancer ER− | Breast cancer ER+ | ||||
Locus | Base pair | Lead SNP | Gene | A1 | A2 | β (SE) | P overall |  | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value |
Percent dense volume | ||||||||||||||
 10q25.3 | 115,248,851 | rs2089176 | HABP2 | A | G | − 0.07 (0.01) | 4.1 × 10− 9 | 0.36 | 0.98 (0.97–0.99) | 0.01 | 1.00 (0.98–1.03) | 0.70 | 0.97 (0.96–0.99) | 5.3 × 10− 4 |
Absolute dense volume | ||||||||||||||
 2q14.2 | 121,092,388 | rs12468790 | INHBB | A | G | 0.08 (0.01) | 2.1 × 10− 8 | 0.40 | 0.97 (0.96–0.98) | 4.8 × 10− 6 | 0.93 (0.91–0.95) | 1.5 × 10− 9 | 0.98 (0.96–0.99) | 3.8 × 10− 3 |
 17q24.3 | 67,836,371 | rs9302903 | LINC01483 | T | C | − 0.14 (0.02) | 5.9 × 10− 9 | 0.09 | 0.96 (0.94–0.99) | 1.1 × 10− 3 | 0.98 (0.94–1.02) | 0.26 | 0.95 (0.93–0.98) | 1.5 × 10− 4 |