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Table 2 Novel loci associated with volumetric mammographic density

From: Common genetic variation and novel loci associated with volumetric mammographic density

       Karma-OncoArray (n = 5827) Karma-iCOGS (n = 4021) Karma pooled MD analysis (N = 9848)
Locus Base pair Lead SNP Gene A1 A2 MAF β (SE) P value MAF β (SE) P value β (SE) P overall P value for heterogeneity
Percent dense volume
 10q25.3 115,248,851 rs2089176 HABP2 A G 0.41 − 0.05 (0.01) 3.2 × 10− 4 0.41 − 0.08 (0.02) 1.4 × 10− 6 − 0.07 (0.01) 4.1 × 10− 9 0.20
Absolute dense volume
 2q14.2 121,092,388 rs12468790 INHBB A G 0.39 0.08 (0.02) 2.4 × 10− 5 0.36 0.08 (0.02) 2.3 × 10− 4 0.08 (0.01) 2.1 × 10− 8 0.84
 17q24.3 67,836,371 rs9302903 LINC01483 T C 0.08 − 0.12 (0.03) 7.5 × 10− 5 0.08 − 0.17 (0.04) 1.3 × 10− 5 − 0.14 (0.02) 5.9 × 10− 9 0.36
  1. Abbreviations: iCOGS Illumina iSelect genotyping array of the Collaborative Oncological Gene-environment Study, Karma Karolinska Mammography Project for Risk Prediction of. Breast Cancer, SNP Single-nucleotide polymorphism, A1 Major allele, A2 Minor allele, MAF Minor allele frequency
  2. Gene refers to nearest gene. All lead SNPs were imputed: INFO scores Karma-OncoArray: rs2089176 (0.99), rs12468790 (0.96), rs9302903 (0.99)