Table 2 Novel loci associated with volumetric mammographic density
From: Common genetic variation and novel loci associated with volumetric mammographic density
| Â | Â | Â | Â | Â | Â | Karma-OncoArray (n = 5827) | Karma-iCOGS (n = 4021) | Karma pooled MD analysis (N = 9848) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Locus | Base pair | Lead SNP | Gene | A1 | A2 | MAF | β (SE) | P value | MAF | β (SE) | P value | β (SE) | P overall | P value for heterogeneity |
Percent dense volume | ||||||||||||||
 10q25.3 | 115,248,851 | rs2089176 | HABP2 | A | G | 0.41 | − 0.05 (0.01) | 3.2 × 10− 4 | 0.41 | − 0.08 (0.02) | 1.4 × 10− 6 | − 0.07 (0.01) | 4.1 × 10− 9 | 0.20 |
Absolute dense volume | ||||||||||||||
 2q14.2 | 121,092,388 | rs12468790 | INHBB | A | G | 0.39 | 0.08 (0.02) | 2.4 × 10− 5 | 0.36 | 0.08 (0.02) | 2.3 × 10− 4 | 0.08 (0.01) | 2.1 × 10− 8 | 0.84 |
 17q24.3 | 67,836,371 | rs9302903 | LINC01483 | T | C | 0.08 | − 0.12 (0.03) | 7.5 × 10− 5 | 0.08 | − 0.17 (0.04) | 1.3 × 10− 5 | − 0.14 (0.02) | 5.9 × 10− 9 | 0.36 |