Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability

Table 2 Univariate and multivariate Cox regression analysis of IDH1 expression for disease-specific survival and disease-free survival of patients with breast IDC

Characteristic	Number (percentage)	DSS				DFS
Characteristic	Number (percentage)	CHR^a (95% CI)	p value	AHR^b (95% CI)	p value	CHR^a (95% CI)	p value	AHR^b (95% CI)	p value
IDH1 status	(n = 249)
High (5–7)	164 (65.9)	1.00		1.00		1.00		1.00
Low (0–4)	85 (34.1)	1.64 (1.14–2.38)	*0.008*	1.57 (1.08–2.30)	*0.020*	1.58 (1.07–2.34)	*0.023*	1.40 (0.93–2.10)	0.106

Abbreviations: IDH isocitrate dehydrogenase, IDC invasive ductal carcinoma, DSS disease-specific survival, DFS disease-free survival, CHR crude hazard ratio, AHR adjusted hazard ratio
^aCHRs were estimated by univariate Cox regression
^bAHRs were adjusted for American Joint Committee on Cancer pathological stage (II and III vs. I), grading (III vs. I and II), incomplete or inappropriate adjuvant treatment vs. non-treatment or complete adjuvant treatment, and molecular subtypes (luminal B, human epidermal growth factor receptor 2 overexpression and basal-like vs. luminal A) in multivariate Cox regression
Bold italic values denote statistically significant

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