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Table 2 Univariate and multivariate Cox regression analysis of IDH1 expression for disease-specific survival and disease-free survival of patients with breast IDC

From: Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability

Characteristic Number (percentage) DSS DFS
CHRa (95% CI) p value AHRb (95% CI) p value CHRa (95% CI) p value AHRb (95% CI) p value
IDH1 status (n = 249)         
High (5–7) 164 (65.9) 1.00   1.00   1.00   1.00  
Low (0–4) 85 (34.1) 1.64 (1.14–2.38) 0.008 1.57 (1.08–2.30) 0.020 1.58 (1.07–2.34) 0.023 1.40 (0.93–2.10) 0.106
  1. Abbreviations: IDH isocitrate dehydrogenase, IDC invasive ductal carcinoma, DSS disease-specific survival, DFS disease-free survival, CHR crude hazard ratio, AHR adjusted hazard ratio
  2. aCHRs were estimated by univariate Cox regression
  3. bAHRs were adjusted for American Joint Committee on Cancer pathological stage (II and III vs. I), grading (III vs. I and II), incomplete or inappropriate adjuvant treatment vs. non-treatment or complete adjuvant treatment, and molecular subtypes (luminal B, human epidermal growth factor receptor 2 overexpression and basal-like vs. luminal A) in multivariate Cox regression
  4. Bold italic values denote statistically significant