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Table 1 Correlation of ΙDΗ1 expression with clinicopathological characteristics of patients with IDC of the breast

From: Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability

Variables IDH1
% Mean ± SD Median p value
Age (years)
  <40 16.9 4.07 ± 2.13 5.00 0.068a
 40–59 55.1 4.85 ± 1.87 6.00  
60 28.1 4.67 ± 2.06 5.00  
Menopausal status
 Perimenopausal and premenopausal 47.6 4.51 ± 2.00 5.00 0.225b
 Postmenopausal 52.4 4.80 ± 1.97 6.00  
Grading
 Well-differentiated + moderately differentiated 77.2 4.79 ± 1.95 5.00 0.070b
 Poor 22.8 4.26 ± 2.06 4.00  
Pathology stage
 I 15.7 5.38 ± 1.55d, e 6.00 0.012 c
 II 49.1 4.64 ± 2.02d 5.00  
 III 35.2 4.38 ± 2.05e 5.00  
pT stage
 T1 25.1 4.93 ± 1.79 5.00 0.186a
 T2 64.4 4.66 ± 2.01 5.00  
 T3 + T4 10.5 4.11 ± 2.20 4.50  
pN stage
 N0 40.4 5.06 ± 1.78f, g 6.00 0.018 c
 N1 26.6 4.34 ± 2.06f 5.00  
 N2 22.8 4.26 ± 2.24g 5.00  
 N3 10.1 4.85 ± 1.73 5.00  
Vascular invasion
 Absent 62.9 4.73 ± 1.95 5.50 0.524b
 Present 37.1 4.57 ± 2.05 5.00  
Nipple invasion
 Absent 90.6 4.69 ± 2.00 5.00 0.622b
 Present 9.4 4.48 ± 1.83 5.00  
  1. IDH isocitrate dehydrogenase, IDC invasive ductal carcinoma
  2. ap values were estimated by one-way analysis of variance (ANOVA)
  3. bp values were estimated by Student’s t test
  4. cp values were estimated by Kruskal–Wallis one-way ANOVA
  5. dp = 0.027, stage I compared with stage II
  6. ep = 0.003, stage I compared with stage III
  7. fp = 0.006, stage N0 comapred with stage N1
  8. gp = 0.013, stage N0 comapred with stage N2
  9. Bold italics values denote statistically significant
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