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Table 1 Correlation of ΙDΗ1 expression with clinicopathological characteristics of patients with IDC of the breast

From: Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability

Variables

IDH1

%

Mean ± SD

Median

p value

Age (years)

  <40

16.9

4.07 ± 2.13

5.00

0.068a

 40–59

55.1

4.85 ± 1.87

6.00

 

60

28.1

4.67 ± 2.06

5.00

 

Menopausal status

 Perimenopausal and premenopausal

47.6

4.51 ± 2.00

5.00

0.225b

 Postmenopausal

52.4

4.80 ± 1.97

6.00

 

Grading

 Well-differentiated + moderately differentiated

77.2

4.79 ± 1.95

5.00

0.070b

 Poor

22.8

4.26 ± 2.06

4.00

 

Pathology stage

 I

15.7

5.38 ± 1.55d, e

6.00

0.012 c

 II

49.1

4.64 ± 2.02d

5.00

 

 III

35.2

4.38 ± 2.05e

5.00

 

pT stage

 T1

25.1

4.93 ± 1.79

5.00

0.186a

 T2

64.4

4.66 ± 2.01

5.00

 

 T3 + T4

10.5

4.11 ± 2.20

4.50

 

pN stage

 N0

40.4

5.06 ± 1.78f, g

6.00

0.018 c

 N1

26.6

4.34 ± 2.06f

5.00

 

 N2

22.8

4.26 ± 2.24g

5.00

 

 N3

10.1

4.85 ± 1.73

5.00

 

Vascular invasion

 Absent

62.9

4.73 ± 1.95

5.50

0.524b

 Present

37.1

4.57 ± 2.05

5.00

 

Nipple invasion

 Absent

90.6

4.69 ± 2.00

5.00

0.622b

 Present

9.4

4.48 ± 1.83

5.00

 
  1. IDH isocitrate dehydrogenase, IDC invasive ductal carcinoma
  2. ap values were estimated by one-way analysis of variance (ANOVA)
  3. bp values were estimated by Student’s t test
  4. cp values were estimated by Kruskal–Wallis one-way ANOVA
  5. dp = 0.027, stage I compared with stage II
  6. ep = 0.003, stage I compared with stage III
  7. fp = 0.006, stage N0 comapred with stage N1
  8. gp = 0.013, stage N0 comapred with stage N2
  9. Bold italics values denote statistically significant