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Fig. 5 | Breast Cancer Research

Fig. 5

From: Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability

Fig. 5

Isocitrate dehydrogenase 1 (IDH1) was involved in modulating breast cancer motility through mitogen-activated protein kinase (MAPK) signaling. a Western blot analysis of IDH1, p-extracellular signal-regulated kinase (ERK) 1/2, ERK1/2, snail, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were present in MDA-MB-231 cells transfected with si-IDH1 and scramble control (N.C). b and c Cell invasion ability of IDH knockdown MDA-MB-231 cells with and without U0126 treatment. The relative invasion ability was further quantified using Ascent software

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Breast Cancer Research

ISSN: 1465-542X

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