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Fig. 6 | Breast Cancer Research

Fig. 6

From: Murine breast cancer feed arteries are thin-walled with reduced α1A-adrenoceptor expression and attenuated sympathetic vasocontraction

Fig. 6

Arterial contractions in response to electrical field stimulation of perivascular sympathetic nerve endings are reduced in breast cancer feed arteries compared to matched control arteries. a Original traces showing contractions of breast cancer feed arteries and control arteries elicited by electrical field stimulation. b, c Concentration-response curves showing frequency-dependent contractions of breast cancer feed arteries and control arteries (n = 5–6) in response to electrical field stimulation (EFS) (b, c) and their inhibition by tetrodotoxin (TTX) (b) and prazosin (c). The curves are the results of least-squares fits to sigmoidal functions, and we compared them using the extra-sum-of-squares F test. ***P < 0.001. NS: not significantly different vs. control under similar conditions

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Breast Cancer Research

ISSN: 1465-542X

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