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Fig. 3 | Breast Cancer Research

Fig. 3

From: Murine breast cancer feed arteries are thin-walled with reduced α1A-adrenoceptor expression and attenuated sympathetic vasocontraction

Fig. 3

Media stress of breast cancer feed arteries is reduced compared to matched control arteries in response to norepinephrine and U46619 but not in response to endothelin-1 or depolarization with elevated extracellular K+ concentration ([K+]o). Media stress (wall tension divided by media thickness) during stimulation with 300 nmol/L endothelin-1 (a) (n = 19), 80 mmol/L K+o (b) (n = 16), 30 μmol/L norepinephrine (c) (n = 24), and 3 μmol/L U46619 (d) (n = 11). Experiments with elevated [K+]o were performed in the presence of 1 μmol/L phentolamine in order to avoid the effects of norepinephrine released from sympathetic nerve endings in response to depolarization. Data were compared by the paired two-tailed Student’s t test. Responses to U46619 were log-transformed before statistical comparison to achieve normal distribution. *P < 0.05, **P < 0.01, NS: not significantly different vs. control

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