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Fig. 2 | Breast Cancer Research

Fig. 2

From: Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers

Fig. 2

Copy number variation profiles of ataxia-telangiectasia mutated (ATM)-associated tumours analysed with the OncoScan array. a Genome-wide view of cumulative copy number variations present in the 23 ATM-associated tumours. Gains are indicated in red, losses in blue, and loss of heterozygosity (LOH) in orange. b Cluster dendrogram and genomic regions altered in ≥ 70% of the 23 analysed tumours. Tumours from Ataxia-telangiectasia (A-T) children are indicated by asterisks. c Cluster dendrogram and genomic regions altered in ≥ 70% of the 16 tumours with confirmed biallelic inactivation of ATM. Tumours from A-T children are indicated by asterisks. Loss The two alleles are present in the tumour, Loss/LOH Only one allele is present in the tumour, Loss/LOH or Loss Consecutive segmental regions characterised as either ‘Loss/LOH’ or ‘Loss’, HBOC Hereditary breast and ovarian cancer, HER2 Human epidermal growth factor receptor 2

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