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Fig. 5 | Breast Cancer Research

Fig. 5

From: Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer

Fig. 5

NUAK family kinase 1 (NUAK1) inhibition is phosphatase and tensin homolog-synthetic sick/lethal (PTEN-SSL) in breast cancer cell lines. a Sensitivity of 11 PTEN+ and 8 PTEN- breast cancer cell lines to HTH-01-015 and WZ4003, small molecule inhibitors of NUAK1 kinase; *p < 0.05, two-sided Wilcoxon rank-sum test. b HTH-01-015 dose-response curves in isogenic PTEN+ and PTEN- models derived from MCF-10A (left) and MDA-MB-231 (right) cell lines;**p < 0.01, *p < 0.05, two-sided t test on four biological replicates. IC50, concentration required to reduce cell viability by 50%

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