Fig. 2
From: Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer
Identification of phosphatase and tensin homolog-synthetic sick/lethal (PTEN-SSL) genes in the MCF-10A cell line. a Cell line viability responses to ~ 21,000 short interfering RNA (siRNA) pools in two replicate screens. Each dot represents siRNA pool. b The z scores for three types of screening control: non-silencing (NS), essential gene (PLK1), and PTEN-SSL gene (CDC25A). Whiskers indicate 95th and 5th percentiles; ***p < 0.0001 (Wilcoxon rank-sum test). Each dot represents one control siRNA pool. c siRNA z scores from two replicate screens. Each dot represents one siRNA pool