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Table 3 Association of %MD categories prior to/at first diagnosisa and post diagnosisb with CBC risk by age

From: The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study

 

CBC

Number (%)

UBC

Number (%)

ORc (95% CI)

Percent mammographic density prior to/at diagnosis

   

Age <45 years

   

  <25%

18 (20)

30 (30)

0.46 (0.20, 1.05)

 25 to <50%

46 (51)

49 (49)

1.00

  ≥50%

26 (29)

21 (21)

2.22 (0.94, 5.25)

Age 45 to <50 years

   

  <25%

19 (23)

25 (27)

0.86 (0.36, 2.06)

 25 to <50%

39 (48)

46 (49)

1.00

  ≥50%

24 (29)

22 (24)

1.22 (0.51, 2.89)

Age 50–54 years

   

  <25%

30 (37)

26 ((34)

0.87 (0.37, 2.04

 25 to <50%

40 (49)

35 (46)

1.00

  ≥50%

11 (14)

15 (20)

0.60 (0.21, 1.68)

p interaction

  

0.39

Post diagnosis

Age <45 years

   

  <25%

42 (34)

71 (52)

0.51 (0.27, 0.96)

 25 to <50%

55 (45)

51 (37)

1.00

  ≥50%

26 (21)

15 (11)

1.70 (0.71, 4.05)

Age 45 to <50 years

   

  <25%

36 (33)

57 (45)

0.60 (0.31, 1.16)

 25 to <50%

54 (49)

57 (45)

1.00

  ≥50%

20 (18)

13 (10)

1.70 (0.68, 4.22)

Age 50–54 years

   

 <25%

51 (51)

53 (47)

0.98 (0.52, 1.87)

 25 to <50%

43 (43)

47 (42)

1.00

  ≥50%

6 (6)

13 (12)

0.51 (0.16, 1.87)

p interaction

  

0.06

  1. Abbreviations: %MD percent mammographic density, CBC contralateral breast cancer, UBC unilateral breast cancer, OR odds ratio, CI confidence interval
  2. aPrior to/at 1st diagnosis was 36 months prior up to 1 month post diagnosis
  3. bPost diagnosis was > 6 months up to 48 months post diagnosis
  4. cOR adjusted for study center, race (non-Hispanic white versus other), age at mammogram, menopausal status at mammogram, estimated body mass index at mammogram, age at first diagnosis, age at menarche, number of full-term pregnancies, first-degree family history of breast cancer, histologic type, stage, and estrogen receptor status of first diagnosis, chemotherapy, radiation, and tamoxifen use after first diagnosis