Table 5 Correlation of SLC7A5 expression with the expression of other related genes in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) data

 MYC

0.133 (2.4 × 10⁻⁹)

<0.0001

0.012 (0.752)

4.145

0.155 (0.001)

0.019

0.066 (0.310)

4.650

0.103 (0.062)

0.434

 mTOR

0.085 (0.0001)

0.001

−0.005 (0.904)

1.824

0.088 (0.052)

0.728

−0.023 (0.723)

5.784

0.067 (0.226)

1.130

 VEGFA

0.352 (6.4 × 10⁻⁵⁹)

<0.0001

0.166 (0.000008)

0.0002

0.260 (5.3 × 10⁻⁹)

<0.0001

0.269 (0.00002)

0.0005

0.244 (0.000008)

0.0002

 HIF2A

−0.050 (0.028)

0.168

−0.023 (0.536)

4.896

0.215 (0.000002)

<0.0001

0.112 (0.083)

1.328

−0.282 (1.8 × 10⁻⁷)

<0.0001

 ATF4

0.159 (1.0 × 10⁻¹²)

<0.0001

− 0.029 (0.433)

5.100

0.057 (0.208)

2.080

0.143 (0.026)

0.468

0.108 (0.050)

0.450

 GLS

0.048 (0.032)

0.192

0.008 (0.829)

3.428

0.055 (0.222)

1.998

−0.006 (0.927)

4.635

−0.115 (0.038)

0.456

 ALDH4A1

−0.053 (0.019)

0.133

0.018 (0.638)

4.512

0.063 (0.163)

1.793

−0.028 (0.663)

5.967

−0.134 (0.015)

0.225

 PRODH

0.004 (0.858)

1.716

−0.034 (0.369)

4.763

−0.032 (0.483)

2.415

0.037 (0.573)

5.73

0.030 (0.582)

1.746

 PYCR1

0.32 (1.5 × 10⁻⁵⁰)

<0.0001

0.143 (0.0001)

0.001

0.253 (1.3 × 10⁻⁸)

<0.0001

0.210 (0.001)

0.024

0.303 (1.9 × 10⁻⁸)

<0.0001

 ALDH18A1

0.222 (1.6 × 10⁻²³)

<0.0001

0.151 (0.00004)

0.0008

0.144 (0.001)

0.018

0.168 (0.009)

0.180

0.356 (2.9 × 10⁻¹¹)

<0.0001

 GLUL

−0.18 (3.3 × 10⁻¹⁶)

<0.0001

0.134 (0.0003)

0.005

0.008 (0.863)

1.726

−0.001 (0.991)

1.982

−0.122 (0.028)

0.392

 GLUD1

−0.38 (4.3 × 10⁻⁶⁹)

<0.0001

− 0.161 (0.00001)

0.0002

− 0.237 (1.1 × 10⁻⁷)

<0.0001

−0.148 (0.022)

0.418

−0.112 (0.042)

0.420

 SLC1A5

0.29 (4.5 × 10⁻⁴¹)

<0.0001

0.170 (0.000005)

0.0001

0.150 (0.001)

0.017

0.208 (0.001)

0.023

0.25 (0.000002)

<0.0001

 SLC3A2

0.17 (1.1 × 10⁻¹⁴)

<0.0001

0.067 (0.072)

3.780

0.193 (0.00001)

0.0002

0.184 (0.004)

0.084

0.158 (0.004)

0.064

 SLC6A19

0.004 (0.869)

1.738

0.041 (0.273)

4.428

−0.008 (0.859)

2.577

0.047 (0.473)

5.676

−0.103 (0.061)

0.488

 SLC7A6

0.362 (2.7 × 10⁻⁶²)

<0.0001

0.254 (5.3 × 10⁻¹²)

<0.0001

0.33 (2.0 × 10^{− 14})

<0.0001

0.284 (0.000008)

0.0002

0.071 (0.201)

1.206

 SLC7A7

0.19 (4.6 × 10⁻¹⁹)

<0.0001

0.007 (0.857)

2.712

0.085 (0.061)

0.793

0.041 (0.530)

5.830

−0.22 (0.00005)

0.0001

 SLC7A8

−0.42 (1.1 × 10⁻⁸⁸)

<0.0001

−0.115 (0.002)

0.034

−0.103 (0.022)

0.352

−0.203 (0.002)

0.044

−0.40 (3.9 × 10^{− 14})

<0.0001

 SLC7A9

− 0.068 (0.002)

0.01

0.025 (0.510)

4.82

0.044 (0.333)

2.331

−0.123 (0.056)

0.952

0.283 (1.8 × 10⁻⁷)

<0.0001

 SLC38A1

−0.10 (0.000003)

<0.0001

−0.041 (0.270)

3.549

0.039 (0.391)

2.346

0.053 (0.413)

5.369

0.113 (0.041)

0.451

 SLC38A2

−0.055 (0.015)

0.120

−0.074 (0.048)

1.05

−0.103 (0.022)

0.330

0.007 (0.917)

5.502

−0.119 (0.032)

0.416

 SLC38A3

0.18 (8.3 × 10⁻¹⁷)

<0.0001

0.140 (0.0001)

0.002

0.046 (0.311)

2.488

0.003 (0.958)

2.874

0.196 (0.0003)

0.005

 SLC38A5

0.011 (0.627)

2.574

−0.069 (0.066)

1.08

−0.077 (0.090)

1.080

−0.017 (0.793)

5.551

−0.017 (0.757)

1.514

 SLC38A7

0.306 (3.8 × 10⁻⁴⁴)

<0.0001

0.270 (2.0 × 10⁻¹³)

<0.0001

0.32 (1.2 × 10⁻¹³)

<0.0001

0.064 (0.324)

4.536

0.177 (0.001)

0.017

 SLC38A8

0.023 (0.312)

1.560

−0.019 (0.612)

4.466

0.011 (0.801)

3.204

−0.006 (0.930)

3.720

−0.039 (0.482)

1.928